11 results about "Afferent nerves" patented technology

Embodiments treat inflammation of a user by applying a first patch on a dermis of the user adjacent to an afferent nerve, the first patch comprising first electrodes, and applying a second patch on the dermis of the user adjacent to a vagus nerve or a vagus nerve connecting branch, the second patch comprising second electrodes. Embodiments generate a treatment protocol during a time period comprising simultaneously applying a first electrical stimuli to the afferent nerve via the first electrodes of the first patch and applying a second electrical stimuli to the vagus nerve or the vagus nerve connecting branch via the second electrodes of the second patch.

In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.

The present invention provides a method and pharmaceutical composition for treating overactive bladder (OAB) and / or bladder pain syndrome (BPS) comprising a viral expression vector carrying a transcription cassette containing a transgene that inhibits / silences neurotransmission or synaptic transmission of an afferent neuron.

Methods and systems for monitoring, preventing and / or treating upper airway disorders such as apnea, dysphagia, reflux and / or snoring are described. The methods and systems monitor the upper airway disorders by processing one or more neural signals obtained from one or more upper airway afferents. Upper airway disorders are prevented and / or treated by delivering one or more stimulations to one or more reflex-related afferents, efferents, muscles, and sensory receptors to manipulate the threshold and / or trigger an upper airway reflex including, but not limited to a swallow reflex and / or a negative-pressure reflex.

The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting / silencing neurotransmission or synaptic transmission of afferent neurons.

Disclosed is an afferent neuron circuit, which includes: a resistance Rc and a volatile threshold switching device TS, wherein the volatile threshold switching device TS is provided with a parasitic capacitor Cparasitic; a first end of the resistance Rc serves as a signal input terminal, and a second end of the resistance Rc serves as a signal output terminal; and a first end of the volatile threshold switching device TS is connected to the signal output terminal, and a second end of the volatile threshold switching device TS is grounded. The afferent neuron circuit provided in the content of the present disclosure has a simple structure and good scalability and is suitable for large-scale integration.

In an illustrative embodiment, systems and methods for treating kidney disease in a human patient are disclosed. A method includes advancing a collapsible array of RF electrodes through a urinary tract of the patient in collapsed form and into a position in or near a renal pelvis. The effector is deployed to an expanded form to engage at least a portion of an interior wall of the renal pelvis. RF energy delivered through the array of electrodes target afferent nerves proximate the interior wall of the renal pelvis to inhibit or destroy their function. eGFR of the patient can be raised after treatment according to the method.

Systems and methods are directed to influencing organ function by stimulating the dorsal root ganglion. Systems include at least one electrode to deliver electrical stimulation to the dorsal root ganglion to activate afferent nerves innervating at least one organ, and computing apparatus comprising one or more processors operably coupled to the at least one electrode to control the electrical stimulation.

The present invention provides a method and pharmaceutical composition for the treatment of overactive bladder (OAB) and / or bladder pain syndrome (BPS), comprising a viral expression vector having a transcription cassette containing one or more transgenes that inhibit / silence neurotransmission or synaptic transmission of afferent neurons.

The present invention relates to the technical field of urination control, and specifically to an implantable bionic urination control system comprising neuroelectrophysiological detection: by performing neuroelectrophysiological detection on peripheral nerves, damaged units are detected; an electrical signal monitoring module: the electrical signal monitoring module is connected to the upstream of the damaged nerve unit to monitor the input of nerve signals; an electrical signal output module: the electrical signal output module is connected to the damaged electrical signal monitoring module, and the electrical signal output module is connected to the downstream of the damaged nerve unit; a central controller: the central controller comprises a power supply unit and a control unit, and the electrical signal output module is connected to the electrical signal monitoring module and the control unit; the beneficial effect of the present invention is that through the arrangement of the electrical signal monitoring module and the electrical signal output module, the damaged parts of the afferent nerves or efferent nerves can be reconnected, thereby ensuring that the peripheral nerve loop is unobstructed and that the patient can urinate normally.