Pyrazole derivative, or pharmaceutically acceptable salt thereof

A pharmacology and compound technology, applied in the field of pyrazole derivatives or their pharmacologically acceptable salts, can solve the problems of different compound structures, no record or suggestion of TRPM8 inhibitors, different structures, etc.
CN107709301AActive Publication Date: 2018-02-16KISSEI PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KISSEI PHARMA
Publication Date
2018-02-16

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Abstract

The purpose of the present invention is to provide a novel pyrazole derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same and a pharmaceutical usethereof. The present invention provides a composition having a TRPM8 inhibitory activity and represented by formula (I) (in the formula, ring A is C6-10 aryl or the like, X is CR4a or the like, R1 and R2 are a hydrogen atom or the like, R3 is a hydrogen atom or the like, R4 is a hydrogen atom or the like, ring B is C6-10 aryl or the like, R5 is a hydrogen atom or the like, R6a is a hydrogen atomor the like, R7a is a hydrogen atom or the like, R7b is a hydrogen atom or the like, R6b is a hydrogen atom or the like, R8 is a hydrogen atom or the like, and n is 0, 1, or 2), or a pharmaceuticallyacceptable salt thereof. Furthermore, the composition of the present invention represented by formula (I) or the pharmaceutically acceptable salt thereof can be used as a therapeutic agent or prophylactic agent for diseases or conditions caused by hyperexcitability or disorders of afferent nerves.
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Description

technical field

[0001] The present invention relates to a pyrazole derivative useful as a medicine or a pharmacologically acceptable salt thereof, a pharmaceutical composition containing the same, and its medical use. Background technique

[0002] Transient Receptor Potential (TRP) channels are non-selective cation channels activated by various stimuli such as temperature and chemicals, and are divided into TRPM, TRPA, TRPV, TRPC, TRPP, TRPML, TRPN families . In addition, TRPM1, TRPM2, TRPM3, TRPM4a, TRPM4b, TRPM5, TRPM6, TRPM7, and TRPM8 are known as TRPM families (for example, refer to Non-Patent Document 1).

[0003] TRPM8 is the eighth channel of the TRPM family cloned in 2002 (for example, refer to Non-Patent Document 2), and is also known as CMR1 (cold and menthol sensitive receptor-1, cold and menthol sensitive receptor 1), Activated by cold stimulation at 8°C to 28°C or chemical substances (menthol, icilin) ​​that induce low temperature sensation (for example, refe...

Claims

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