Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

System and method for monitoring and treating arrhythmia and cardiac function via intrinsic cardiac nervous system

A technology for endogenous and ischemic heart disease, applied in cardiac electrodes, spinal cord nerve electrodes, applications, etc., can solve problems such as limited understanding

Inactive Publication Date: 2018-02-16
RGT UNIV OF CALIFORNIA
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the functional consequences of these changes on neural signaling in vivo in the context of healing infarcts have not been directly documented and are limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • System and method for monitoring and treating arrhythmia and cardiac function via intrinsic cardiac nervous system
  • System and method for monitoring and treating arrhythmia and cardiac function via intrinsic cardiac nervous system
  • System and method for monitoring and treating arrhythmia and cardiac function via intrinsic cardiac nervous system

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0074] Example 1: Myocardial infarction alters cardiac neural signature and induces neural remodeling

[0075]The experiments presented herein were designed to examine morphological and phenotypic remodeling within the ICNS and to directly assess remodeling of ICNS processing of afferent and efferent inputs (sympathetic and parasympathetic), and the afferent and outgoing input via LCN integration. The effect of cardiac pacing was also studied. Pacing is directly relevant to understanding from a mechanistic point of view why strategies to minimize device-assisted ventricular pacing in patients have been shown to benefit survival in patients with ischemic heart disease in clinical trials.

[0076] This paper demonstrates that MI induces morphological and neurochemical changes within ICNS. This structure reshapes the functional changes in the processing of incoming and outgoing neural signals in this neural network in parallel. The heterogeneity of afferent neural signals co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention includes systems and methods for measuring, monitoring and managing arrhythmia and cardiac function through an intrinsic cardiac nervous system. The system and method compare theneurological signatures of the intrinsic cardiac nervous system associated with the healthy heart muscle tissue and diseased heart muscle tissue to identify and scale incoming afferent intrinsic cardiac nerve cells whose signal transmission has been affected by diseased heart tissues. Therefore, a method of modulating afferent nerve signals from the diseased myocardium to the higher centers of the intrinsic cardiac nervous system, the intrathoracic extracardiac ganglion, and the cardiac nerve axis is used as a novel treatment method for ischemic heart diseases.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application No. 62 / 150,463, filed April 21, 2015, the contents of which are hereby incorporated by reference in their entirety. Background of the invention [0003] Sudden cardiac death (SCD) caused by ventricular arrhythmias is a major cause of high mortality worldwide, resulting in an estimated four to five million deaths per year (Chugh et al., 2008,. Progress in cardiovascular diseases, 51(3): 213-28). Dysregulation of the autonomic nervous system (ANS) after myocardial infarction (MI) plays a key role in the development of arrhythmias and the development of heart failure (Vaseghi and Shivkumar, 2008, Prog Cardiovasc Dis, 50(6):404-19; Shen and Zipes, 2014, Circulation Research; 114(6):1004-21). The cardiac nerve axis is responsible for the dynamic regulation of cardiac electrical and mechanical functions (Armour, 2004, Am J Physiol Regul Integr CompPhysiol;...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0464A61B5/363
CPCA61B5/4836A61B5/4839A61N1/0551A61N1/056A61N1/0587A61N1/36114A61B5/24A61B5/287A61B5/363A61B5/388
Inventor K·西弗库玛J·L·阿德尔
Owner RGT UNIV OF CALIFORNIA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com