Imidazoyl pyridine compounds and salts thereof

a technology of pyridine and pyridine, which is applied in the field of pharmaceuticals, can solve the problems of high efficacy of non-peptidic compounds which inhibit the production of a40 and a42, and have not yet been known
US20110065696A1Inactive Publication Date: 2011-03-17KIMURA TEIJI +14
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KIMURA TEIJI
Publication Date
2011-03-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

A compound represented by the formula (I):or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
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Description

RELATED APPLICATIONS

[0001] The present application is a 37 CFR §1.53(b) divisional of U.S. application Ser. No. 12 / 200,731 filed Aug. 28, 2008, which claims priority of U.S. Provisional Application No. 60 / 935,824 filed Aug. 31, 2007, U.S. Provisional Application No. 61 / 025,099 filed Jan. 31, 2008, and U.S. Provisional Application No. 61 / 051,751 filed May 9, 2008. The contents of each of these applications are hereby incorporated by reference.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention relates to a pharmaceutical, more particularly, to a multi-cyclic cinnamide derivative effective for treatment of a neurodegenerative disease caused by amyloid-β (hereinafter referred to as Aβ) such as Alzheimer's disease or Down's syndrome and a medicine, in particular, a medicine for prevention or treatment of a disease caused by Aβ comprising the derivative as an active ingredient.

[0004] 2. Description of Related Art

[0005] Alzheimer's disease is a disease chara...

Claims

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