Compositions Comprising Plant Extracts and Use Thereof for Treating Inflammation
a technology of plant extracts and compositions, applied in the direction of plant ingredients, biocide, plant growth regulators, etc., can solve the problems of affecting the most basic motor skills, affecting the protection of immune responses, and a plethora of adverse effects
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example 1
Carrageenin-Induced Acute Inflammation in Mice
[0068]Phenylbutazone, Celebrex, Naproxen and individual plant extract compositions as described in Table V were suspended / dissolved in a vehicle of 2% Tween 80.
[0069]Male CD-1 (Crl.) derived mice weighing 22±1 g were obtained from BioLasco Taiwan (under Charles River Laboratories Technology Licensee). All animals were housed in a controlled temperature (22° C.-24° C.) and humidity (60%-80%) environment with 12 hours light / dark cycles for at least one week prior to experimental use. The animals had free access to standard lab chow for mice (MF-18 (Oriental Yeast Co., Ltd., Japan) and Reverse Osmosis water was granted. All aspects of the study including housing, experimentation and disposal of animals were performed in general accordance with the Guide for the Care and Use of Laboratory Animals (National Academy Press, Washington, D.C., 1996).
[0070]Groups of 5 CD-1 male mice were fasted overnight prior to use. The test substances were admi...
example 2
Methods of Treating Adjuvant-Induced Arthritis in Rats
[0072]The study was conducted in male Lewis rats obtained from Charles River Japan, Inc. The animals were housed in a controlled temperature (21° C.-24° C.) and humidity (54%-68%) environment with 12 hour light / dark cycles for at least 1 week prior to use. Rats had Laboratory Rodent Diet MF-18 (Oriental Yeast Co., Ltd., Japan) and water (reverse osmosis purified water) ad libitum. The entire study and animal conditions and manipulations were conducted in accordance with the Guide for the Care and Use of Laboratory Animals (National Academy Press, Washington, D.C., 1996).
[0073]Eight groups of 5 rats weighing approximately 210±10 g were used. Anti-inflammatory composition 5, Phenylbutazone, Celebrex, Dexamethasone and 2% Tween 80 were administered orally once daily for 5 consecutive days, with the first dose given one hour before Complete Freund's Adjuvant (CFA) challenge. Anti-inflammatory composition 5 was administered at 25 or 6...
example 3
Mono-Iodoacetate (MIA) Chemically-Induced Osteoarthritis in Rats
[0076]A total of seventy (70) male Sprague-Dawley rats plus five (5) spares (Harlan Sprague Dawley, Inc., Indianapolis, Ind., USA) were used. The animals were pathogen free and of approximately 12 weeks of age upon start of experiments. There were 10 animals per group. The animals were individually housed in clear polycarbonate plastic cages but received enrichment in the way of Enrich-o-cobs bedding. The animals were acclimated for a minimum of 7 days prior to the start of the experimental procedures. The temperature was maintained at 18-26° C. (64-79° F.) with a relative humidity of 30-70%. Animals had ad libitum access to certified Pico rodent diet and water (deionized water system).
[0077]Animals were allocated to the treatment groups as specified in Table VII based on baseline von Frey results. The mean values of the groups were then reviewed to ensure that the groups were homogeneous.
[0078]Animals were first anesth...
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