Anti-inflammatory modalities

a technology of ibs and ibs, applied in the field of anti-inflammatory modalities, can solve the problems of cholestasis, liver failure, hepatocellular injury, etc., and achieve the effect of avoiding cardiovascular side effects

Inactive Publication Date: 2012-03-08
MARSHALL EDWARDS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The isoflavonoid compounds effectively reduce inflammation and pain in inflammatory disorders, including IBD, without cardiovascular side effects, and demonstrate cardioprotective and gut-protective properties, offering a more selective and less toxic treatment option compared to existing therapies.

Problems solved by technology

Additionally, none of the existing therapies are without significant side effects.
In PSC and PBC, the bile ducts become inflammed, scarred and eventually blocked, causing cholestasis, hepatocellular injury and in many cases liver failure.
Although several studies have reported a lower prevalence of IBS among older people, the present studies do not allow to definitely conclude whether or not an age disparity exists in IBS.

Method used

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  • Anti-inflammatory modalities
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Examples

Experimental program
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examples

Synthetic Methods for Substituted Isoflavanones and Isoflavan-4-ols

[0141]Condensation of 2-bromoresorcinol with 4-hydroxyphenylacetic acid—Synthesis of 1-(3-bronio-2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)-ethanone

[0142]Borontrifluoride diethyl etherate (30 ml ) was added to a mixture of 2-bromoresorcinol (5.0 g, 26 mmoles) and 4-hydroxyphenylacetic acid (3.0 g, 26 mmoles) in a round bottom flask fitted with a condenser and a magnetic stirrer. The mixture was heated at 100-110° C. for one and a half hour with stirring. The mixture was then cooled to room temperature and kept in a freezer overnight. The precipitated solid was filtered and recrystallised from ethanol to give deoxybenzoin as off-white crystals. The crystals were then collected and dried in a desiccator. 1H NMR (CDCl3): δ 4.16 (s, 2H, CH2), 6.61 (d, 1H, J 9.0 Hz, ArH), 6.80 (d, 2H, J 8.6 Hz, ArH), 7.12 (d, 1H, J 8.6 Hz, ArH), 7.75 (d, 1H, J 9.0 Hz, ArH). Yield: 5.2g, 69%

[0143]Cyclisation of 1-(3-brorno-2,4-dihydroxypheny...

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Abstract

Anti-inflammatory modalities are described with reference to select isoflavonoid compounds, compositions containing same and the use of said compounds and / or compositions in treatment, particularly for the treatment of inflammatory diseases and related conditions.

Description

FIELD OF THE INVENTION[0001]The present invention relates to certain isoflavonoid compounds, compositions containing same and the use of said compounds and / or compositions in treatment, particularly for the treatment of inflammatory diseases and conditions. Inflammatory conditions include irritable bowel disease (IBD), for example: ulcerative colitis (UC), ulcerative proctitis, distal colitis; and / or Crohn's disease (CD), as well as other hepatointestinal syndromes including primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH) and irritable bowel syndrome (IBS).BACKGROUND OF THE INVENTION[0002]UC causes inflammation of the inner lining of the large bowel (colon and rectum). CD causes inflammation of the full thickness of the bowel wall and may involve any part of the digestive tract from the mouth to the anus. CD can cause recurrent bowel obstruction, fistulae, abscess formation and sepsis as well as extra-intestinal manifestations such a...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): C07D311/38A61P29/00A61P9/12A61P19/02A61P11/06A61P9/10C07D311/58A61P19/08
CPCC07D493/04A61P1/00A61P1/04A61P11/00A61P11/06A61P19/02A61P19/08A61P29/00A61P35/00A61P3/06A61P35/02A61P37/00A61P37/06A61P43/00A61P5/30A61P9/00A61P9/10A61P9/12
InventorWALKER, CATHERINEHUSBAND, ALAN JAMESJAMES, MICHAEL JOHN
OwnerMARSHALL EDWARDS INC