Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules

a detection device and detection rate technology, applied in the field of biological molecules detection devices having increased detection rate, and a method for quick detection of biological molecules, can solve the problems of short hybridization time and limitations of detection chambers presently exploited in microfluidic devices for biological analysis, and achieve the effect of increasing the detection ra

Inactive Publication Date: 2012-03-22
STMICROELECTRONICS SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach significantly reduces detection time to less than one minute by increasing the hybridization rate and mobility of target DNA, allowing for faster analysis of biological samples.

Problems solved by technology

The detection chambers presently exploited in microfluidic devices for biological analysis have some limitations.
Interactions between a probe and its corresponding target are accordingly quite unlikely and hybridization takes a very long time.

Method used

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  • Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules
  • Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules
  • Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules

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Experimental program
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Effect test

second embodiment

[0057]According to the invention, illustrated in FIG. 14, a detecting device 40 comprises the detection array 21, a field array 41, the probe driver circuit 25 and field driver circuit 24 (here not shown). The detection array 21 is arranged on a dielectric layer 43, which is in turn deposited on the bottom wall 7a of the detection chamber 7. The field array 41 comprises a plurality of metal field electrodes 42, which are embedded in the dielectric layer 43. Also in this case, the field electrodes 42 are preferably interleaved with the probes 26, both by rows and columns.

third embodiment

[0058]the invention is illustrated in FIG. 15. In particular, a detecting device 50, instead of being monolithically integrated with the semiconductor body 2, comprises a field array 51 of metal field electrodes 52, which are formed on the transparent plate 18. In particular, the metal field electrodes 52 are carried on a surface on the transparent plate 18, which upwardly delimits the detection chamber 7. In practice, the field array 51 is separately manufactured and is assembled to the semiconductor body 2, which accommodates the detection array 21, the probe driver circuit 25 and the field driver circuit 24 (not shown), by bonding the transparent plate 18. Hence, fabrication of the detecting device is simplified.

fourth embodiment

[0059]According to the invention shown in FIG. 16, in a detecting device 60 the probes 26 include probe DNA 101, which is directly anchored to a common dielectric basement layer 61 covering the field electrodes 30 of the field array 22. In this case, the probe electrodes 27 and the probe driver circuit 25 are not present.

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Abstract

A biological molecule detection device that includes a detection array, arranged on a body and having one or more probes for detecting corresponding electrically charged molecules, wherein a time varying electric field generating circuit is provided for generating at least one time varying electric field around the detection array within the detection region. The time varying electric field moves the electrical charged molecules repeatedly back and forth over the probes, thus providing increased opportunities for interaction and speeding the detection process.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to EP 04425535.4, filed Jul. 19, 2004, and is incorporated in its entirety herein by reference.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not applicable.REFERENCE TO A COMPACT DISK APPENDIX[0003]Not applicable.BACKGROUND OF THE INVENTION[0004]The present invention relates to a biological molecules detection device having increased detection rate, and to a method for quick detection of biological molecules.[0005]Typical procedures for analyzing biological materials, such as nucleic acid, involve a variety of operations starting from raw material. These operations may include various degrees of cell purification, lysis, amplification or purification, and analysis of the resulting amplified or purified product.[0006]As an example, in DNA-based blood tests the samples are often purified by filtration, centrifugation or by electrophoresis so as to eliminate all the non-nucleated cells....

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): C40B60/12
CPCB01J2219/00527G01N33/5438B01J2219/00659B01J2219/00707B01J2219/00722B01L3/50273B01L3/502761B01L7/52B01L2200/10B01L2300/0636B01L2300/0645B01L2300/0816B01L2300/0867B01L2300/087B01L2300/1827B01L2400/0424B01L2400/049G01N27/44713B01J2219/00653
InventorPALMIERI, MICHELEFISCHETTI, ALESSANDRA
OwnerSTMICROELECTRONICS SRL