Permissive cells and uses thereof

a technology of permissive cells and cells, applied in the field ofvirology, can solve the problems of loss of induction of important neutralizing antibodies, inability to produce and release infectious progeny viruses, and even inability to carry out some cell types, so as to increase the permissivity of partially susceptible cells and enhance the production of viruses
US20140186395A1Inactive Publication Date: 2014-07-03UNIV GENT ENGLISH TRANSLATION BEING GHENT UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNIV GENT ENGLISH TRANSLATION BEING GHENT UNIV
Publication Date
2014-07-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described are methods for determining the permissiveness of a cell for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular, for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Further described are methods and compositions related to the generation of host cells permissive for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular, for PRRSV. Methods of utilzing the cells thus identified or thus generated, in preparing a culture of a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, as well as the use of the virus for the purpose of vaccine production or diagnosis, are also described.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of co-pending U.S. patent application Ser. No. 12 / 452,675, filed Jan. 13, 2010, U.S. patent Ser. No. ______, which application is a national phase entry under 35 U.S.C. §371 of International Patent Application PCT / EP2008 / 006045, filed Jul. 23, 2008, designating the United States of America and published in English as International Patent Publication WO 2009 / 024239 A2 on Feb. 26, 2009, which claims the benefit under Article 8 of the Patent Cooperation Treaty and under 35 U.S.C. §119(e) to Great Britain Patent Application Serial No. 0811278.1 filed Jun. 19, 2008, and to European Patent Application Serial No. 07014842.4 filed Jul. 27, 2007, the disclosure of each of which is hereby incorporated herein by this reference in its entirety.TECHNICAL FIELD

[0002] The disclosure relates generally to the field of virology. More particularly, it relates to methods for determining the permissiveness of a cell for a vir...

Claims

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