Three-component formulations, methods and procedures, and combinations thereof, for reducing or preventing the development, or the risk of development, of neuropathology resulting from trauma

a neuropathology and three-component technology, applied in the field of multi-component formulations, can solve the problems of unresolved medical needs, damage caused by secondary processes as serious and extensive, and cell loss caused by primary injuries beyond treatment, so as to reduce or prevent the development or the risk of development, optimal treatment to prevent or reduce secondary injuries, and maximize the effect of process control

US20140193528A1Inactive Publication Date: 2014-07-10SAPNA LIFE SCI
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
Publication Date
2014-07-10
Estimated Expiration
Not applicable · inactive patent
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Abstract

Novel three-component formulations, procedures and methods for use in treating neuropathology incident to trauma are provided. Three-component formulations of the invention comprise biologically active forms of at least one neurosteroid, at least one anti-epileptic or anticonvulsant, and at least one lithium-containing or lithium-related compound. The provided formulations are configured or adapted to prevent or reduce the incidence and severity of neurological damage caused by neurotrauma. Formulations, procedures and methods of the invention advantageously effect both neuroprotective actions to prevent or reduce secondary injuries, and neurotrophic actions to repair and restore cells and tissues affected by the trauma, and are especially useful in treating neurological trauma, such as those caused by sports injuries, chemical weapons, vehicle collisions and improvised explosive devices in combat.
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Description

RELATED APPLICATION AND PRIORITY

[0001] This Utility patent application claims the priority and benefit of commonly owned U.S. Provisional Patent Application Ser. No. 61 / 750,745 of James L. Henry, as filed 9 Jan. 2013, and as entitled “Formulations, Methods And Procedures For Reducing Or Preventing The Development Or The Risk Of Development Of Neuropathology As A Result Of Traumatic Injury” which provisional patent application is hereby incorporated by reference in its entirety into the present patent application. Also hereby incorporated by reference in their entireties are each of the references cited herein, as well as those cited in Provisional Patent Application Ser. No. 61 / 750,745.FIELD OF THE INVENTION

[0002] The presently disclosed invention, and the many particular embodiments of the invention, relate to multiple-component formulations, the use of such formulations, and to methods, procedures and combinations thereof to prevent, eliminate, or reduce, or to reduce the risk of, t...

Examples

Embodiment Construction

[0055]In accordance with these and other objects, the present invention provides many embodiments of its formulations, methods, procedures and means for treating any neuropathological condition that is the result of, or incident to, at least partially, of trauma of any kind. The present formulations, methods and procedures advantageously affect cellular and tissue function, such as endogenous processes or biosynthetic and metabolic process pathways that govern, regulate or influence the health or function of nerves or nerve cells, or cells upon which nerves or nerve cells depend to maintain health and function. As an aspect of the presently disclosed technology, the formulations are preferably in forms and a dosages with respect to each of the respective components such that any of the formulations are adapted and arranged for administration to a mammal in need thereof, such that the development, or the risk of development, of neuropathology is reduced, lessened, attenuated or preve...