Three-component formulations, methods and procedures, and combinations thereof, for reducing or preventing the development, or the risk of development, of neuropathology resulting from trauma

Abstract

Novel three-component formulations, procedures and methods for use in treating neuropathology incident to trauma are provided. Three-component formulations of the invention comprise biologically active forms of at least one neurosteroid, at least one anti-epileptic or anticonvulsant, and at least one lithium-containing or lithium-related compound. The provided formulations are configured or adapted to prevent or reduce the incidence and severity of neurological damage caused by neurotrauma. Formulations, procedures and methods of the invention advantageously effect both neuroprotective actions to prevent or reduce secondary injuries, and neurotrophic actions to repair and restore cells and tissues affected by the trauma, and are especially useful in treating neurological trauma, such as those caused by sports injuries, chemical weapons, vehicle collisions and improvised explosive devices in combat.

Description

RELATED APPLICATION AND PRIORITY[0001]This Utility patent application claims the priority and benefit of commonly owned U.S. Provisional Patent Application Ser. No. 61 / 750,745 of James L. Henry, as filed 9 Jan. 2013, and as entitled “Formulations, Methods And Procedures For Reducing Or Preventing The Development Or The Risk Of Development Of Neuropathology As A Result Of Traumatic Injury” which provisional patent application is hereby incorporated by reference in its entirety into the present patent application. Also hereby incorporated by reference in their entireties are each of the references cited herein, as well as those cited in Provisional Patent Application Ser. No. 61 / 750,745.FIELD OF THE INVENTION[0002]The presently disclosed invention, and the many particular embodiments of the invention, relate to multiple-component formulations, the use of such formulations, and to methods, procedures and combinations thereof to prevent, eliminate, or reduce, or to reduce the risk of, t...

AI Technical Summary

Benefits of technology

The present invention relates to a formulation, method, procedure, and device for treating neuropathological conditions caused by trauma. The invention involves the use of an anticonvulsant / antiepileptic, a neurosteroid / neuroactive steroid, and a lithium drug or analog in a combination or sequence. These compounds can be administered to a subject in need in any formulation, such as a tablet, capsule, pill, spray, solution, paste, cream, or intravenous injection. The invention targets specific biological processes or pathways that promote health and function of nerves and nerve cells, as well as those that lead to loss of function, injury, damage, or death of nerves. The invention can be used to treat any trauma that causes damage to nerves, including but not limited to brain trauma, spinal cord injury, and peripheral nerve damage. The invention also includes the use of pro-drugs, derivatives, metabolites, analogs, salts, or controlled-release forms of the compounds. The invention can be delivered through various routes, such as oral, buccal, mucosal, parenteral, rectal, and more. The invention also includes the use of neural support cells and tissues to support the health, function, and survival of nerves and nerve cells.

Problems solved by technology

This gap represents an unsolved medical need.

Cell loss caused by this primary injury is beyond treatment.

Indeed, the damage caused by these secondary processes can be as serious and extensive as, or even more serious and extensive than, that caused by the primary trauma.

Secondary processes also progress over time so that injury and damage can continue over the days, weeks and even months after the initial injury.