Universal portable machine for online hemodiafiltration using regenerated dialysate

Abstract

Manifolds suitable for use in hemodialysis, hemofiltration, hemodiafiltration, and peritoneal dialysis are provided. One or more of the manifolds can include a manifold body and an external tube. The manifold body can include at least one conduit including a first conduit and at least one port including a first port in fluid communication with the first conduit. The external tube can be in fluid communication with the first port and can include a main segment, a first branch segment, and a second branch segment containing at least one bacterial filter. The first branch segment and/or second branch segment can include at least one flow restrictor. Dialysis machines, systems, and kits including one or more such manifold are also provided, as are methods of performing hemodiafiltration using such manifolds.

Description

FIELD[0001]The present invention relates to materials, machines, systems, and methods for conducting hemodialysis, hemofiltration, hemodiafiltration, and peritoneal dialysis.BACKGROUND OF THE INVENTION[0002]In hemofiltration (HF), solute clearance is achieved through convection, that is, solutes are pulled, along with water, down a pressure gradient. Hemodiafiltration (HDF) combines the concentration-based diffusion of hemodialysis (HD) with hemofiltration. HF generally provides better removal of large molecular weight solutes, improved clearance of low molecular weight uremic toxins, and better cardiovascular stability and blood pressure control than HD. HF can be especially beneficial to long term dialysis patients who are likely to be on dialysis for a long time, and for larger patients in whom it is not possible to achieve sufficient Kt / V with HD. Intradialytic symptoms are often reduced with HF, and residual renal function can be better preserved with HDF. HDF also appears to h...

AI Technical Summary

Benefits of technology

[0005]Another feature of the present invention is to utilize purified dialysate as replacement (ultrafiltration) fluid into the bloodstream to minimize or avoid the use of dedicated, ultrapure replacement fluid, or reliance on additional, cumbersome water purification systems.

Problems solved by technology

The ultrafiltration (UF) aspect of HDF results in loss of fluid.

The reliance on ultrapure water has limited the portability of HDF systems.

The use of highly permeable and high flux membranes, high blood flows, and accurate control of volume replacement also make HDF a complicated undertaking.

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