Rapid image analysis - fleming harrington redistribution wash-in washout method for differentiation of inflammatory vascular disease (IVD) and tissue viability
a vascular disease and inflammatory vascular disease technology, applied in the field of rapid image analysis, can solve the problems of affecting the accuracy of the study, the ability of the artery to dilate and augment the coronary, and the same 35% error rate, so as to achieve the effect of reducing cardiac death, avoiding data loss, and enhancing visual appearan
Active Publication Date: 2016-12-29
FLEMING RICHARD MAX
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Benefits of technology
The present patent provides a method for detecting and differentiating between different types of heart disease. This method can help to improve treatment outcomes and reduce cardiac deaths. It uses a comparison of different parts of the heart to make this differentiation, and can detect areas of damage that may benefit from treatment. The method is designed to be accurate and reliable, and can help to improve the lives of millions of people with heart disease.
Problems solved by technology
This error rate however does not take into account errors made where the area of the heart is incorrect (e.g. ischemia reported in the area of the right coronary artery with angiographic analysis showing it is the left anterior descending artery).
These studies are plagued by the same 35% error rate noted supra.
While Crane reported that sestamibi washout could occur after 28 minutes under ischemic conditions, there is no report indicating this could occur earlier or would be diagnostically useful.
Under these conditions, the major limitation is the ability of the artery to dilate and augment coronary flow to peak levels and a diminished SFR© is seen.
However, under these conditions, the cells have been “temporarily” damaged and with sufficient recovery of blood flow, my return to normal function.
These other methods have not demonstrated clinical utility and most if not all of them have subsequently been abandoned.
These results give a visually pleasing appearance; however, there is no published data as to the “quantitative” reliability of these images.
The 128×128 matrix, while providing a more visually appealing picture for “qualitative” image comparison, was associated with an almost 50% loss of data, yielding inaccurate diagnostic results.
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[0050]Following the discovery that sestamibi “redistributed” and that such “redistribution” could occur as early as five-minutes following venous introduction of the isotope under stress conditions (see FIG. 1), we investigated the “quantitative” characteristics of today's modern Geiger counters (viz. planar, SPECT and PET cameras). For our purposes, we specifically looked at MTF results of the two most common matrixes used for NCS, viz. the 64×64 and 128×128 matrix. Closed system (to prevent loss of isotope) samples of sestamibi were positioned one meter from the camera head of a Philips Forte Dual Head SPECT using a general all-purpose (GAP) collimator and a Picker Axis Dual Head SPECT camera using a low energy general all (LEGAR-PAR) purpose collimator with parallel hole positioning. Counts were acquired for five minutes and recorded and this process was repeated again fifty-five minutes later allowing for 10% isotope decay. This process was done using both the 64×64 and 128×128 ...
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The present invention provides a method for detecting abnormal coronary blood flow by “quantifying” emissions of radiopharmaceuticals after stressing the heart under “same state” conditions for detection of inflammatory vascular (IVD) disease and differentiation of (a) ischemic heart disease due reduced lumen responsiveness to demand for more coronary blood flow and (b) vulnerable inflammatory plaque disease with reduced lumen responsiveness. The present invention also provides a method for detection of myocyte viability by using the “quantitative” method to differentiate “normal” functioning cardiac tissue from non-viable “infarcted” cardiac tissue, from “stunned / hibernating” myocytes. The present invention further provides a method for detection of IVD by detecting enhanced thymic activity associated with IVD. The present invention reduces total patient imaging time, patient table time, radiation isotope doses and exposure to both patient and others through primary and secondary exposure to isotope emissions. In one embodiment, the nuclear isotope is technetium-99m hexakis 2-methoxyisobutylisonitrile (sestamibi).
Description
FIELD OF THE INVENTION[0001]The present invention relates to methods for (a) detecting “Inflammation and Vascular Disease” (© TX 7-451-244) (IVD) including but not limited to ischemic coronary artery disease (IHD) and vulnerable inflammatory plaque (VIP) disease and (b) tissue viability differentiating “normal” myocardium from “stunned / hibernating” or “infarcted” myocardium, using “quantitative” comparisons of tissue under same state conditions. The present invention also relates to a method for differentiation tissue damage and differentiating between “normal” tissue, dead / necrotic tissue (infarction) and that which has been injured sufficiently to impair function (stunned / hibernating), yet is presently recoverable. Finally, the present invention provides a method for further detection of IVD by demonstrating increased uptake of the isotopes by the thymus gland, with evidence of increased thymus gland enlargement and elevations in hs-CRP.BACKGROUND OF THE INVENTION[0002]Conventiona...
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IPC IPC(8): A61B6/00A61B6/03
CPCA61B6/503A61B6/5217A61B6/037A61B6/486G16H50/30
Inventor FLEMING, RICHARD MAX
Owner FLEMING RICHARD MAX