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Method for detecting or treating triple negative breast cancer

a breast cancer and triple negative technology, applied in the field of triple negative breast cancer detection or treatment, can solve the problems and achieve the effect of increasing the risk of tnbc and high risk of tnb

Pending Publication Date: 2017-06-22
CHILDRENS MEDICAL CENT CORP
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Benefits of technology

The patent describes a method for detecting and localizing triple negative breast cancer (TNBC) using a composition of matter that binds an anti-ICAM-1 antibody to a nanoparticle. The method involves quantifying the expression level of ICAM-1 in a sample of human breast tissue and comparing it to a predetermined standard level. If the expression level is greater than the standard level, the human breast tissue is considered to have a high risk of TNBC. The method can also be used to localize the nanoparticle near TNBC cells in the breast tissue. The composition of matter is made by binding the anti-ICAM-1 antibody to a nanoparticle, which can be used as an imaging agent or a therapeutic targeting agent. Overall, this invention provides a novel approach for detecting and treating TNBC.

Problems solved by technology

Overexpression of ICAM-1 is linked to an increased risk of TNBC.

Method used

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  • Method for detecting or treating triple negative breast cancer
  • Method for detecting or treating triple negative breast cancer
  • Method for detecting or treating triple negative breast cancer

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Embodiment Construction

[0038]This disclosure pertains to methods for detecting triple negative breast cancer (TNBC) utilizing intercellular adhesion molecule-1 (ICAM-1) as a target and biomarker. ICAM-1 serves as a TNBC therapeutic target that enables development of multiple types of TNBC-targeted treatments based on the high affinity ICAM-1 ligands (natural and designed) or antibodies targeting with TNBC tumors, including monoclonal antibodies, antibody-drug conjugates, liposomes and nanoparticles. The disclosed methods may be applied in TNBC-targeted treatments based on the overexpression of ICAM-1 in TNBC tissues and cells and the ICAM-1's function in TNBC metastasis, which is involved with cell apoptosis. This disclosure also pertains to the overexpression of intercellular adhesion molecule-1 (ICAM-1, CD54) in human TNBC cell lines and tissues, and demonstrates that ICAM-1 is an effective 1NBC biomarker for TNBC-targeted diagnosis and therapy.

[0039]Triple negative breast cancers (TNBCs) have high mort...

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Abstract

A method of detecting triple negative breast cancer (TNBC) is provided. Overexpression of ICAM-1 is linked to an increased risk of TNBC. A composition of matter is also provided that binds an anti-ICAM˜1 antibody to a nanoparticle. The composition may be used as an imaging agent and / or a therapeutic targeting agent. A therapeutically active molecule may be bound to the composition to provide targeted therapy.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to and is a non-provisional of U.S. provisional patent application Ser. No. 61 / 970,943 (filed Mar. 27, 2014), the entirety of which is hereby incorporated by reference.STATEMENT OF FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made with Government support under Contract No. 1DP2CA17449501 awarded by the National Institute of Health (NIH).BACKGROUND OF THE INVENTION[0003]The subject matter disclosed herein relates to methods for detecting or treating triple negative breast cancer. Triple negative breast cancers (TNBCs) have high mortality owing to aggressive proliferation and metastasis and a lack of diversified treatment options. TNBCs, which represent 15 to 20 percent of breast cancers, occur more frequently in young women, African American women, and individuals carrying the BRCA1 gene. Currently, there is no curative treatment for TNBC, and the available chemotherapy is associated ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/4965A61K31/4365G01N33/574A61K9/14C12Q1/68A61K31/429A61K31/191
CPCA61K31/4965A61K31/429A61K31/4365A61K31/191A61K9/14A61K2121/00C12Q1/6886G01N33/57415C12Q2600/158G01N2333/70525A61K47/4813A61K47/555
Inventor AUGUSTE, DEBRAMOSES, MARSHA A.GUO, PENG
Owner CHILDRENS MEDICAL CENT CORP
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