Systems and methods for fault diagnosis in molecular networks
a molecular network and fault diagnosis technology, applied in the field of molecular biology medicine, can solve the problems of affecting the efficacy and efficiency of signal transduction within the network, pathology cannot be linked to a single gene, hindering and complicating diagnosis/treatment of pathology
Inactive Publication Date: 2017-07-06
ABDI ALI +1
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Benefits of technology
This method enables the identification of key molecules contributing to disease states, providing insights for diagnosis and potential drug targets, and has been demonstrated to be biologically relevant in pathways like p53 and CREB, aligning with known disease mechanisms.
Problems solved by technology
(Papin et al., 2005; Klipp et al, 2005; Gomperts et al., 2002) Accordingly, dysfunction of any such biomolecules may interfere with the efficacy and efficiency of signal transduction within the network.
Such dysfunction may consequently result in a cell transitioning from a normal state of cellular function (physiological condition) to a diseased state (pathological condition).
However, in the case of some of the most prevalent and incurable human diseases, such as neurodegenerative / psychiatric brain disorders and cancer, the pathology cannot be linked to a single gene.
Thus, in such disorders, the main cause of pathology is typically unknown or poorly understood, thus hindering and complicating diagnosis / treatment of the pathology.
Thus, a high vulnerability value for a molecule indicates a high probability that dysfunction of said molecule will disrupt the system and thereby change the system from a physiological state to a pathological state.
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[0045]Advantageous systems and methods for identifying molecular vulnerabilities in biological pathways are disclosed herein. The disclosed systems and methods generally involve modeling a biological system as a digital logic circuit and then using probability propagation algorithms to determine molecular vulnerabilities. In exemplary embodiments, the disclosed systems and methods may be used to facilitate the diagnosis, isolation and / or treatment of disease.
[0046]The currently disclosed systems and methods involve modeling a disorder at the molecular level as a faulty system, in which one or more molecules in the complex intracellular network are dysfunctional. As noted above, recent progress in genome-wide and proteome-wide expression analysis of biological systems provides a valuable picture of the “expression levels” of the molecules. According to exemplary embodiments of the present disclosure, the “functionality” of each molecule determines the overall performance of the mole...
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The present disclosure provides advantageous systems and methods for identifying molecular vulnerabilities in biological pathways and networks. The present disclosure generally involves conceptualizing a disease / disorder at the molecular level as a faulty physiological system, wherein one or more molecules in the complex intracellular signaling network are dysfunctional. This is accomplished by modeling a given physiological system as a digital logic circuit. More particularly, in exemplarily embodiments, binary logic equations are derived by analyzing the interactions between the input and output nodes of a target biological system. These equations are then used to produce a digital circuit representation for the system. Once a digital circuit representation is created, this circuit may advantageously be analyzed, using fault analysis techniques, in order to determine the vulnerability levels of the molecules of the targeted system.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 13 / 006,901, filed Jan. 14, 2011, now U.S. Pat. No. 9,542,641, which is a continuation of U.S. application Ser. No. 12 / 527,269, which claims the benefit of international application No PCT / US2008 / 054674 filed Feb. 22, 2008, and U.S. Provisional Patent Application No. 60 / 902,767 filed Feb. 22, 2007, the entirety of each of these is hereby incorporated herein by reference into this application.BACKGROUND[0002]1. Technical Field[0003]The present disclosure generally relates to the field of molecular biology medicine. More particularly, the present disclosure relates to systems and methods for studying biological networks and for computing molecular vulnerabilities in connection with such networks and pathways. The present disclosure implicates a wide range of applications including, but not limited to, drug research / development, disease diagnosis, gene therapy, and the lik...
Claims
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IPC IPC(8): G06F19/00G06F19/12G06F19/26G16B5/20G16B45/00
CPCG06F19/3431G06F19/12G06F19/26B82Y10/00G16B5/00G16B45/00G06N3/002G16H50/30Y02A90/10G16B5/20
InventorABDI, ALIEMAMIAN, EFFAT S.
OwnerABDI ALI