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System and method for imaging and illumination for cell confluence measurement

Inactive Publication Date: 2020-06-18
CORNING INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The patent describes a system and method for imaging cells in trays using illumination and imaging systems that are placed next to each other. This arrangement allows for back illumination of the cells while still using a compact and functional system. The invention can be easily integrated into existing monitoring plates for industry standard cell culturing vessels. By having the illumination and imaging systems next to each other, they can be pre-aligned and take up minimal space in the cell growth trays, which means there is no space wasted by a camera system. This minimizes the space needed and creates an image of the cells by rear illumination.

Problems solved by technology

Any space taken up by a camera system is space that cannot be used for cell growth.

Method used

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  • System and method for imaging and illumination for cell confluence measurement
  • System and method for imaging and illumination for cell confluence measurement
  • System and method for imaging and illumination for cell confluence measurement

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Embodiment Construction

[0031]Reference will now be made in detail to the present embodiment(s), an example(s) of which is / are illustrated in the accompanying drawings. Whenever possible, the same reference numerals will be used throughout the drawings to refer to the same or like parts.

[0032]All scientific and technical terms used herein have meanings commonly used in the art unless otherwise specified. Any definitions provided herein are to facilitate understanding of certain terms used frequently herein and are not meant to limit the scope of the present disclosure.

[0033]The present disclosure is described below, at first generally, then in detail on the basis of several exemplary embodiments. The features shown in combination with one another in the individual exemplary embodiments do not all have to be realized. In particular, individual features may also be omitted or combined in some other way with other features shown of the same exemplary embodiment or else of other exemplary embodiments.

[0034]The...

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Abstract

A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.

Description

RELATED APPLICATIONS[0001]This application is a continuation of International Application No. PCT / US2019 / 063712 filed on Nov. 27, 2019, which claims the benefit of priority under 35 U.S.C § 120 of U.S. Provisional Application Ser. No. 62 / 773,899 filed on Nov. 30, 2018, both applications being incorporated herein by reference.FIELD OF THE INVENTION[0002]This invention pertains to the field of laboratory work, and, in particular, to the equipment and methods used in a laboratory environment for imaging of microscopic structures such as cells. More particularly, the present disclosure relates to systems and methods for measurement of cell culture confluence.BACKGROUND OF THE INVENTION[0003]Cell culture is an indispensable tool that has found many important and valuable applications in a wide range of areas such as drug screening, toxicity testing, genetic engineering, therapeutic protein and vaccine production. In general, mammalian cell lines are cultured in an incubator, where it is ...

Claims

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Application Information

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IPC IPC(8): C12M1/32G01N33/50
CPCC12M23/12G02B21/04G01N33/5005G02B21/002G02B21/36C12M41/46C12M23/04C12M23/22C12M31/08C12M31/10G01N21/55G01N33/4833G02B21/361
Inventor COBB, JOSHUA MONROEMARTIN, GREGORY ROGERRACZKOWSKI, ROBERT RAYMONDSANSON, MARK CHRISTIANSCHREIBER, HORSTUPTON, TODD MICHAEL
Owner CORNING INC
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