DNA encoding interleukin-B30

a technology of interleukin and dna, applied in the field of proteins, can solve the problems of hampered research to better understand and treat various immune disorders

Inactive Publication Date: 2006-03-14
MERCK SHARP & DOHME CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Research to better understand and treat various immune disorders has been hampered by the general inability to maintain cells of the immune system in vitro.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019]All references cited herein are incorporated herein by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

OUTLINE

I. General

II. Purified IL-B30

[0020]A. physical properties

[0021]B. biological properties

III. Physical Variants

[0022]A. sequence variants, fragments

[0023]B. post-translational variants[0024]1. glycosylation[0025]2. others

IV. Functional Variants

[0026]A. analogs, fragments[0027]1. agonists[0028]2. antagonists

[0029]B. mimetics[0030]1. protein[0031]2. chemicals

[0032]C. species variants

V. Antibodies

[0033]A. polyclonal

[0034]B. monoclonal

[0035]C. fragments, binding compositions

VI. Nucleic Acids

[0036]A. natural isolates; methods

[0037]B. synthetic genes

[0038]C. methods to isolate

VII. Making IL-B30, mimetics

[0039]A. recombinant methods

[0040]B. synthetic methods

[0041]C. natural purification

VIII. Uses

[0042]A. diagnostic

[0043]B. therapeutic

IX. Kits

[0044]A. nucleic acid rea...

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PUM

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Abstract

Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.

Description

[0001]This application is a conversion of provisional U.S. patent application U.S. Ser. No. 60 / 053,765, filed Jul. 25, 1997, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention pertains the compositions related to proteins which function in controlling biology and physiology of mammalian cells, e.g., cells of a mammalian immune system. In particular, it provides purified genes, proteins, antibodies, and related reagents useful, e.g., to regulate activation, development, differentiation, and function of various cell types, including hematopoietic cells.BACKGROUND OF THE INVENTION[0003]Recombinant DNA technology refers generally to the technique of integrating genetic information from a donor source into vectors for subsequent processing, such as through introduction into a host, whereby the transferred genetic information is copied and / or expressed in the new environment. Commonly, the genetic information exists in the form of complementary DNA...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): C12N15/24C07K14/54C12N15/63C12N5/10A61K38/00C07H21/04
CPCC07K14/54C07H21/04A61K38/00A61K2039/505Y10T436/143333
Inventor BAZAN, J. FERNANDO
Owner MERCK SHARP & DOHME CORP
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