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DNA encoding interleukin-B30

a technology of interleukin and dna, applied in the field of proteins, can solve the problems of hampered research to better understand and treat various immune disorders

Inactive Publication Date: 2006-03-14
MERCK SHARP & DOHME CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a new cytokine called IL-B30 and its biological activities. The invention includes nucleic acids coding for IL-B30 and methods for producing and using it. The invention also provides a substantially pure or recombinant IL-B30 protein or peptide, as well as a fusion protein comprising IL-B30. The invention also includes a kit for detecting or purifying IL-B30. The invention has various applications, such as modulating or intervening in the control of growth factor-dependent physiology or immune response. The invention also includes a binding compound that specifically binds to IL-B30. The invention provides a new tool for research and development in the field of cytokine biology.

Problems solved by technology

Research to better understand and treat various immune disorders has been hampered by the general inability to maintain cells of the immune system in vitro.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019]All references cited herein are incorporated herein by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.

OUTLINE

I. General

II. Purified IL-B30

[0020]A. physical properties

[0021]B. biological properties

III. Physical Variants

[0022]A. sequence variants, fragments

[0023]B. post-translational variants[0024]1. glycosylation[0025]2. others

IV. Functional Variants

[0026]A. analogs, fragments[0027]1. agonists[0028]2. antagonists

[0029]B. mimetics[0030]1. protein[0031]2. chemicals

[0032]C. species variants

V. Antibodies

[0033]A. polyclonal

[0034]B. monoclonal

[0035]C. fragments, binding compositions

VI. Nucleic Acids

[0036]A. natural isolates; methods

[0037]B. synthetic genes

[0038]C. methods to isolate

VII. Making IL-B30, mimetics

[0039]A. recombinant methods

[0040]B. synthetic methods

[0041]C. natural purification

VIII. Uses

[0042]A. diagnostic

[0043]B. therapeutic

IX. Kits

[0044]A. nucleic acid rea...

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Abstract

Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.

Description

[0001]This application is a conversion of provisional U.S. patent application U.S. Ser. No. 60 / 053,765, filed Jul. 25, 1997, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention pertains the compositions related to proteins which function in controlling biology and physiology of mammalian cells, e.g., cells of a mammalian immune system. In particular, it provides purified genes, proteins, antibodies, and related reagents useful, e.g., to regulate activation, development, differentiation, and function of various cell types, including hematopoietic cells.BACKGROUND OF THE INVENTION[0003]Recombinant DNA technology refers generally to the technique of integrating genetic information from a donor source into vectors for subsequent processing, such as through introduction into a host, whereby the transferred genetic information is copied and / or expressed in the new environment. Commonly, the genetic information exists in the form of complementary DNA...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): C12N15/24C07K14/54C12N15/63C12N5/10A61K38/00C07H21/04
CPCC07K14/54C07H21/04A61K38/00A61K2039/505Y10T436/143333
Inventor BAZAN, J. FERNANDO
Owner MERCK SHARP & DOHME CORP
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