Use of carbazole compounds for the treatment of congestive heart failure

a technology of congestive heart failure and carbazole, which is applied in the direction of biocide, drug composition, peptide/protein ingredients, etc., can solve the problems of abnormal retention of water, excess mortality, and congestive heart failure, and achieve the effect of decreasing mortality
USRE40707E1Inactive Publication Date: 2009-05-05SMITHKLINE BEECHAM (CORK) LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
SMITHKLINE BEECHAM (CORK) LTD
Publication Date
2009-05-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of treatment using carvedilol is disclosed, wherein the carvedilol decreases the risk of mortality caused by congestive heart failure in patients. The patients are titrated with low amounts of carvedilol, with the initial titration dosage being only 10 to 30% of the daily maintenance dose.
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Description

[0001] This application is a 371 of PCT / EP96 / 00498 filed Feb. 7, 1996.FIELD OF THE INVENTION

[0002] The present invention relates to a new method of treatment using compounds which are dual non-selective β-adrenoceptor and α1-adrenoceptor antagonists in particular the carbazolyl-(4)-oxypropanolamine compounds of Formula I, preferably carvedilol, for decreasing the mortality of patients suffering from congestive heart failure (CHF). The invention also relates to a method of treatment using compounds which are dual non-selective β-adrenoceptor and α1-adrenoceptor antagonists, in particular the carbazolyl-(4)-oxypropanolamine compounds of Formula I, preferably carvedilol, in conjunction with one or more other therapeutic agents, said agents being selected from the group consisting of angiotensin converting enzyme (ACE) inhibitors, diuretics, and cardiac glycosides, for decreasing the mortality of patients suffering from CHF. The invention further relates to an incremental application sche...

Claims

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