Application of Tianshen capsule in preparation of drug for treating hyperlipidemia

Abstract

The invention discloses application of Tianshen capsule in preparation of a drug for treating hyperlipidemia. By the Tianshen capsule, TC (total cholesterol) and TG (triglyceride) in serum of a hyperlipidemia rat can be effectively reduced, and the content of HDL-C (high-density lipoprotein-cholesterol) in serum of the hyperlipidemia rat is improved; and therefore, the Tianshen capsule has a function of reducing blood fat, can be used for adjusting lipid metabolism and preventing ankylosing spondylitis (AS) and coronary heart diseases (CHD).

Description

technical field

[0001] The invention belongs to the field of medicine, and relates to the application of Tianshen capsule, in particular to its application in treating hyperlipidemia. Background technique

[0002] Abnormal fat metabolism or operation makes one or more lipids in plasma higher than normal, which is called hyperlipidemia. Hyperlipidemia is a systemic disease, refers to blood total cholesterol (TC) and / or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low, modern medicine is called dyslipidemia . Lipids are insoluble or slightly soluble in water and must be combined with proteins to exist in the form of lipoproteins. Therefore, hyperlipidemia is also commonly referred to as hyperlipoproteinemia. The damage to the body of the disease is insidious, gradual, progressive and systemic. Its direct damage is to accelerate systemic atherosclerosis, because vital organs of the whole body rely on arterial blood supply and oxygen su...

Examples

Embodiment 1

[0009] Experiment of lowering blood fat with Tianshen Capsule

[0010] 1 Materials and methods

[0011] 1.1 Drugs Tianshen Capsules, the content is tan powder, 0.4g / capsule, batch number: 120225, provided by Sanpu Pharmaceutical Co., Ltd.; simvastatin tablets, 20mg / tablet, batch number: 110761, Hangzhou Merck Pharmaceutical Co., Ltd.

[0012] 1.2 Animal experiment Animals: SD male rats, 130~150g, license number: SCXK (Su) 2009-0001, provided by Suzhou Industrial Park Airmate Technology Co., Ltd., in line with SPF standards, and tested after 10 days of normal feeding .

[0013] 1.3 High-fat feed 78.8% of ordinary feed, 1% of cholesterol, 10% of egg yolk powder, 10% of lard and 0.2% of bile salt, provided by the Medical Comparison Center of Yangzhou University.

[0014] 1.4 Reagents Triglyceride kit (Beijing Beihua Kangtai Clinical Reagent Co., Ltd., batch number: 20120524), total cholesterol kit (Beijing Beihua Kangtai Clinical Reagent Co., Ltd., batch number: 20120525), high...

Embodiment 2

[0032] Tianshen capsule is composed of 13% rhodiola rosea, 21% salvia miltiorrhiza, 20% panax notoginseng, 15% chuanmuxiang, 13% medlar, 10% barberry bark, 6% seabuckthorn fresh The slurry is mixed with 2% starch.

Embodiment 3

[0034] Tianshen capsule is composed of 18% rhodiola rosea, 16% salvia miltiorrhiza, 10% panax notoginseng, 18% chuanmuxiang, 20% medlar, 15% barberry bark, 2% seabuckthorn fresh The pulp is mixed with 1% starch.

technical field

[0001] The invention belongs to the field of medicine, and relates to the application of Tianshen capsule, in particular to its application in treating hyperlipidemia. Background technique

[0002] Abnormal fat metabolism or operation makes one or more lipids in plasma higher than normal, which is called hyperlipidemia. Hyperlipidemia is a systemic disease, refers to blood total cholesterol (TC) and / or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low, modern medicine is called dyslipidemia . Lipids are insoluble or slightly soluble in water and must be combined with proteins to exist in the form of lipoproteins. Therefore, hyperlipidemia is also commonly referred to as hyperlipoproteinemia. The damage to the body of the disease is insidious, gradual, progressive and systemic. Its direct damage is to accelerate systemic atherosclerosis, because vital organs of the whole body rely on arterial blood supply and oxygen su...

Examples

Embodiment 1

[0009] Experiment of lowering blood fat with Tianshen Capsule

[0010] 1 Materials and methods

[0011] 1.1 Drugs Tianshen Capsules, the content is tan powder, 0.4g / capsule, batch number: 120225, provided by Sanpu Pharmaceutical Co., Ltd.; simvastatin tablets, 20mg / tablet, batch number: 110761, Hangzhou Merck Pharmaceutical Co., Ltd.

[0012] 1.2 Animal experiment Animals: SD male rats, 130~150g, license number: SCXK (Su) 2009-0001, provided by Suzhou Industrial Park Airmate Technology Co., Ltd., in line with SPF standards, and tested after 10 days of normal feeding .

[0013] 1.3 High-fat feed 78.8% of ordinary feed, 1% of cholesterol, 10% of egg yolk powder, 10% of lard and 0.2% of bile salt, provided by the Medical Comparison Center of Yangzhou University.

[0014] 1.4 Reagents Triglyceride kit (Beijing Beihua Kangtai Clinical Reagent Co., Ltd., batch number: 20120524), total cholesterol kit (Beijing Beihua Kangtai Clinical Reagent Co., Ltd., batch number: 20120525), high...

Embodiment 2

[0032] Tianshen capsule is composed of 13% rhodiola rosea, 21% salvia miltiorrhiza, 20% panax notoginseng, 15% chuanmuxiang, 13% medlar, 10% barberry bark, 6% seabuckthorn fresh The slurry is mixed with 2% starch.

Embodiment 3

[0034] Tianshen capsule is composed of 18% rhodiola rosea, 16% salvia miltiorrhiza, 10% panax notoginseng, 18% chuanmuxiang, 20% medlar, 15% barberry bark, 2% seabuckthorn fresh The pulp is mixed with 1% starch.

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