53results about How to "Inhibition of uptake" patented technology

A fat-reducing health food prepared mainly from the raw materials of konjak, potato, Chinese yam, dasheen, and sweet potato, the raw materials are dried, crushed into powder and mixed. The powdery compound of the invention can eaten directly, and can be made into edible food by any of the conventional methods. The food according to the invention possesses good fat-reducing and health care functions, its advantages includes good taste, no objectionable odor and convenience in carrying.

The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.

The invention discloses camellia sinensisvar assamica Pu'er tea theabrownin and application thereof, and belongs to the technical field of tea processing. The camellia sinensisvar assamica Pu'er tea theabrownin is obtained by the following steps of: a, sterilizing dried green camellia sinensisvar assamica for 30 minutes, adding distilled water inoculated with saccharomyces cerevisiae for food according to the standard that the final water content of the tea is 50 percent, standing for 60 minutes, putting the tea into a full-automatic controlled fermentation box of 40 to 55 DEG C with relativehumidity of 60 to 85 percent after single-layer sealing with a food fresh-keeping film, performing fermentation culture for 40 days, and drying at the temperature of 60 DEG C till the water content is 10 percent to obtain camellia sinensisvar assamica Pu'er tea; and b, crushing the camellia sinensisvar assamica Pu'er tea into 60 to 80 meshes, soaking for 60 minutes in a ratio of tea leaves to boiling water of 1 gram: 60 millimeters, performing filtration to obtain filtrate, sucking 1,000 milliliters of filtrate, adding 4,000 milliliters of edible alcohol, stirring, standing for 4 hours, performing filtration to obtain crude theabrownin extract, dissolving the crude extract by using 20 percent aqueous solution of edible alcohol, and performing traditional concentration and drying on the solution to obtain the theabrownin. The camellia sinensisvar assamica Pu'er tea theabrownin contains protein, polysaccharide and dark brown substances, can remarkably inhibit the absorption and utilization of dietary cholesterol, and can be used as an additive for food and health-care products.

The invention relates to the technical field of oral products, and discloses an oral product containing hyaluronic acid and a preparation method of the oral product. A composition containing the hyaluronic acid comprises a hyaluronic acid composition and fluoride, wherein the hyaluronic acid composition comprises micromolecular hyaluronic acid, medium molecular hyaluronic acid and macromolecular hyaluronic acid, or comprises micromolecular hyarolunate, medium molecular hyaluronate and macromolecular hyaluronate. The prepared oral product is toothpaste, mouthwash, gel, tooth powder or oral spray. According to the invention, fluorine ions released by the fluoride can be attached to a hyaluronic acid film and are slowly released into the tooth surface through the hyaluronic acid film, the anti-caries and remineralization effects of the fluorine ions are gradually achieved, the action time of the fluorine ions is prolonged, and the action effect is enhanced; and meanwhile, the transfer and absorption of the fluorine ions by periodontal tissues and oral mucosa can be avoided, and the irritation is reduced.

The invention relates to a traditional Chinese medicine for treating insulin resistance of type 2 diabetes, and is used for solving the problem that the safe and efficient drugs for treating insulin resistance of type 2 diabetes are not available at present. The traditional Chinese medicine for treating insulin resistance of type 2 diabetes is prepared from the following components in parts by weight: 10-20 parts of American ginseng, 20-40 parts of coix seed and 10-20 parts of alisma. The traditional Chinese medicine has mild drug property and low toxic and side effect, and is used for treating insulin resistance of type 2 diabetes with the main characteristics, such as deficiency of spleen qi and interior accumulation of dampness and turbid. Compared with the similar traditional Chinese medicines, the traditional Chinese medicine has clear main active ingredients and definite disease treatment effect, and can obviously improve insulin resistance of type 2 diabetes.

The invention discloses a biochar-based bacterial composite soil conditioner as well as preparation and application thereof. A preparation method comprises the following steps: (1) domestication of bacteria: sequentially inoculating bacillus cereus, ochrobactrum sp. and arthrobacter sp. into a Cd-containing inorganic salt culture solution with a gradient concentration respectively for domestication and cultivation; and mixing the domesticated and cultured bacterial solutions to prepare a bacterial suspension for later use; and (2) preparation of the biochar-based bacterial composite soil conditioner: taking biochar to be mixed with the bacterial suspension, adding antagonistic elements of heavy metals in soil, then performing shaking cultivation, filtering and washing. The biochar-based bacterial composite soil conditioner provided by the invention is simple in preparation method and low in cost; microorganisms in the preparation have high tolerance to the heavy metal Cd, so that the preparation has good remediation effect on the heavy metals in the soil, and is stable, long-acting, and less affected by the environment; the invention is an in-situ chemistry-combined microbial passivation remediation technology effectively applied to heavy metal-contaminated soil in farmlands.

The invention discloses high-activity water soluble puer tea dietary fiber, and belongs to the technical field of tea processing. The dietary fiber is prepared by the following steps of: crushing cooked puer tea to form 80-mesh particles; mixing 1g of tea and 100ml of de-ionized water, wherein the water temperature is 50 to 80 DEG C; preserving the heat for 12 hours; centrifugally filtering the mixture with a 300-mesh filtering cloth; adding 500 to 2,000u of composite enzyme of cellulase, hemicellulase and pectinase into the mixture of the 1g of tea dreg and 50ml of de-ionized water, wherein the water temperature is 45 DEG C and the pH value is 5.5; preserving the heat for 8 to 12 hours; performing centrifugal filtration and combining the filtrate of the two steps; mixing the filtrate and edible alcohol in the proportion of 1 to 5 and stirring for 15 minutes; standing for 5 hours and centrifugally collecting precipitate; adding 1g of precipitate into 50ml of de-ionized water, dissolving the precipitate, dialyzing the room temperature flowing water in a dialysis bag with molecular interception of 1,500 for 24 hours and collecting dark brown solution which does not pass through the dialysis bag; and concentrating under reduced pressure and performing spray drying to obtain the puer tea dietary fiber. The dietary fiber has low cost, high content of polysaccharide, oligosaccharide and protein, obviously suppresses the adsorption and utilization of dietary cholesterol and is applied to the field of health-care products of foods.

The invention relates to application of N-(3- pyridine formex oxygen radical)-3, 5- dimethyl-1- amantadine or pharmaceutically-acceptable salt for treating vascular dementia.

The invention belongs to the field of biological engineering, and in particular to recombinant expression and purification of a fifth functional domain of an oxLDL binding protein human serum beta 2-glycoprotein I and the application thereof to diagnosis prevention and treatment of atherosclerosis. A designed primers pair is subjected to PCR amplification on a T vector of a beta 2-GPI gene fragment to obtain a gene fragment of a beta 2-GPI fifth functional domain; and pPICZ alpha A-DV is constructed by cloning, and is then subjected to power transformation to obtain a positive strain, which is subjected to recombination and purification to obtain a P.r beta 2-GPI-DV protein. The possibility of using the recombinant protein as a drug in the prevention and treatment of atherosclerosis and the feasibility of detecting the oxLDL content in serum are proved. The P.r beta 2-GPI-DV recombinant protein has purity above 90%, can reduce the content of oxLDL / beta 2-GPI binary compound in the serum, and then inhibit the uptake of oxLDL by scavenger receptors on the surface of macrophage, so as to achieve the effect of preventing and treating atherosclerosis; and because of the combination specificity with oxLDL, the P.r beta2-GPI-DV can realize the specific detection of oxLDL in serum.

Disclosed is a composition for use in the prevention of a hypoglycemic condition, which comprises at least one compound selected from a branched amino acid, a pharmaceutically acceptable salt thereof and a derivative of the amino acid or salt as an active ingredient. The composition can promote the uptake of a saccharide into a brain cell to thereby prevent a hypoglycemic condition.

The invention relates to medical novel applications of cordycepin (3'-deoxyadenosine), and more specifically relates to applications of cordycepin used for preparation of medicines used for preventing and treating atherosclerosis and atherosclerosis related diseases. It is confirmed by pharmacodynamic experiments that: cordycepin is capable of inhibiting formation of ApoE- / - mice aorta atherosclerotic plaques significantly, reducing serum TC, TG, and LDL-c contents of animals with hyperlipidemia, increasing total antioxidant capacity and SOD activity of animal serum, reducing MDA content, reducing contents of serum interleukin 2 and interleukin 8 significantly, and inhibiting inflammation. It is confirmed by cell experiments that: cordycepin is capable of inhibiting uptake of mononuclear cell RAW267.4 on cholesterol significantly, and promoting flowing of cholesterol out from cells.

The invention relates to a pharmaceutical composition, which contains 0.1 to 10 percent amprolium or salt for pharmaceutical use and 0.1 to 5 percent effective iodine and is matched with other additives for preparation. The pharmaceutical composition of the invention makes up the shortcoming that the drugs for the prevention and treatment of various aquatic products on the current market have the single efficacy; at the same time, the invention has the effects of sterilization, disinfection and killing parasites, and has good efficacy on gill rot, hemorrhage and various diseases caused by parasites, bacteria and virus of various fishes, shrimps, crabs, soft-shelled turtles, eels and so on; the invention has good killing function of trichodina, dactylogyrus and other parasites, can also be used in the mixed cultivation pond of fishes, shrimps, crabs and so on, and has significant efficacy which is proved by clinical application.

The invention discloses an optimized chili antibacterial peptide extraction and purification method. Particularly, an inventor acquires the best conditions of chili antibacterial peptide extraction byresearching the influence of different extracting liquid, solid-liquid ratios, extracting time and ammonium sulfate saturability on chili seed antibacterial peptide extraction, and further, components with good antibacterial effects are selected after ultrafiltration and crude separation and subjected to Sephadex gel filtration chromatography to obtain an electrophoresis pure antibacterial peptide sample. The extraction and purification method is simple, the antibacterial effect of an extracted antibacterial peptide is improved by 50.32% as compared with the antibacterial effect before optimization, the antibacterial peptide has a wide antibacterial spectrum, particularly has a strong inhibiting effect on Aspergillus flavus, can effectively inhibit Aspergillus flavus spore germination andmycelial growth and can further inhibit absorption and utilization of nutrient substances in a culture medium by the Aspergillus flavus. The antibacterial peptide extracted by the method is used as acorn mildew preventive, corn quality can be effectively kept, the service life is prolonged, and the antibacterial peptide is better in effect when being used with other mildew preventives.

The invention relates to the technical field of health care products, in particular to a composition for inhibiting expression of advanced glycosylation end products and inhibiting angiosclerosis and a preparation method of the composition. The composition is prepared from the following raw materials in parts by weight: 2 to 20 parts of red grape concentrated powder, 3 to 30 parts of rhizoma curcumae longae, 1 to 20 parts of haematococcus pluvialis astaxanthin microcapsule powder and 1 to 20 parts of emblic leafflower fruit powder. The raw materials can also comprise 3-30 parts of an elderberry extract, 5-50 parts of a blackberry extract and 4-40 parts of a blackcurrant extract. The preparation method is simple and can be used for preparation according to a conventional process. All the components in the composition have a synergistic effect, and the excellent anti-saccharification and blood vessel softening effects are achieved.

The invention discloses a technetium-99m labeled FAPI derivative containing D-proline glycine polypeptide modification and a preparation method and application of the technetium-99m labeled FAPI derivative containing D-proline glycine polypeptide modification, wherein the structural general formula of the technetium-99m labeled FAPI derivative is 99mTc (HYNIC-PGn-FAPI) (Tricine / TPPTS). The < 99m > Tc (HYNIC-PGn-FAP) (trickine / TPPTS) complex is prepared by the following two steps: synthesis of a ligand HYNIC-PGn-FAPI and preparation of the < 99m > Tc (HYNIC-PGn-FAP) (trickine / TPPTS), and the < 99m > Tc (HYNIC-PGn-FAP) (trickine / TPPTS) complex is obtained. The complex is simple and convenient to prepare, high in radiochemical purity and good in stability, has very high uptake and target-to-non-target ratio at the tumor site of a U87MG tumor-bearing mouse, has specific binding with FAP in tumors, and is a novel tumor radiopharmaceutical with clinical application value.

The invention provides a new application of a CPT1a inhibitor, in particular to an application of the CPT1a inhibitor in preparing a medicament for improving drug resistance of solid tumors against anti-vascular drugs. The CPT1a inhibitor acts on the CPT1a on the surface of the mitochondrial outer membrane of tumor cells, inhibits fatty acid from entering the mitochondrial matrix for oxidation, inhibits the uptake of the tumor cells on free fatty acid, recovers the sensitivity of the tumor cells against anti-vascular drug therapy, inhibits the proliferation of the tumor cells, promotes the apoptosis of the tumor cells, and can further achieve the effect of improving the drug resistance of solid tumors against the anti-vascular drugs. The invention also provides a medicament for improving drug resistance of the solid tumor against the anti-vascular drugs and a medicament for treating the solid tumor.

The invention discloses an application of canagliflozin in treatment of pancreatic cancer. The chemical name of the canagliflozin is (1S)-1,5-dehydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl] methyl]-4-methylphenyl]-D-glucitol. A pancreatic cancer tumor cell model and a mouse pancreatic cancer transplantation tumor model are utilized to find that canagliflozin can obviously inhibit the growth and proliferation of pancreatic cancer cells Capan-1 and PANC-1; meanwhile, canagliflozin can inhibit migration of tumor cells; in addition, researches find that canagliflozin can interfere pancreatic cancercell glycolysis related metabolic functions and induce apoptosis of pancreatic cancer cells. The tumor volume of pancreatic cancer subcutaneous transplantation tumor PANC-1 of tumor-bearing mice subjected to canagliflozin treatment is obviously reduced. Therefore, canagliflozin has a bright application prospect in clinical treatment of pancreatic cancer.

The invention relates to an application of protein in preparation of medicines for preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases and peripheral vascular diseases related to atherosclerosis. According to the invention, sDSS1 protein is used for preparing the medicines for preventing and treating the diseases. The sDSS1 protein can effectively reduce the level of oxidized low-density lipoprotein in animal blood of an atherosclerosis model, inhibit the ingestion of vascular endothelial cells and macrophages on oxidized low-density lipoprotein, can increase the intake of oxidized low-density lipoprotein by liver cells and reduce the area of atherosclerotic plaques in model group animals, and inhibit the progress of atherosclerosis or the progress of cardiovascular and cerebrovascular diseases and peripheral vascular diseases caused by atherosclerosis, which has great clinical application value.

The invention relates to the field of pond mariculture, and discloses a method for adjusting the water quality of a mariculture pond by using floating ecological enteromorpha, the method comprises the following seven steps: (1) manufacturing a plastic shed; (2) arranging a plastic shed for pond water feeding; (3) culturing floating ecological enteromorpha in a plastic shed; (4) regulating and controlling the growth water temperature of the floating ecological enteromorpha; (5) culturing floating ecological enteromorpha in a seawater pond; (6) regulating and controlling the water quality of the mariculture pond; and (7) managing the floating ecological enteromorpha. According to the method, the floating ecotype enteromorpha is cultivated by raising the temperature through solar energy through the plastic shed, and then the grown floating ecotype enteromorpha is put into the prism-shaped floating fence in the pond water by stages for enlarged cultivation, so that nutritive salt in the pond water is greatly absorbed and utilized by the floating ecotype enteromorpha, the growth of a large amount of phytoplankton in the pond is inhibited, meanwhile, as a large amount of floating ecological enteromorpha is fished away from the pond, the nutritive salt is taken out, the eutrophication of pond water is eliminated, and remarkable environmental and economic benefits are achieved.

An imaging work station (20) includes one or more processors programmed to receive (170)an image depicting a distribution of a radiotracer in a brain or other region of interest. The radiotracer includes at least one of [18F]-Flutemetamol, [18F]-Florbetaben, and [18F]-Florbetapir which highlights amyloid deposits. The image and a template or an MRI image of the region of interest which includes a segmented anatomical feature, such as gray matter, are registered (180)to a common space. A volume representation of the image which depicts the distribution of the radiotracer in the segmented gray matter and suppresses the radiotracer outside of the segmented anatomical feature in white matter is extracted (210).

The invention discloses a weight-reducing traditional Chinese medicine which comprises the following raw materials by weight: 30 grams of lotus seeds, 15 grams of fructus chaenomelis lagenariae, 10 grams of fructus lycii, 20 grams of mulberry seeds, 20 grams of black beans, 15 grams of ginkgo seeds, 20 grams of peach kernels, 15 grams of lilium brownii and 20 grams of spina date seeds. The weight-reducing traditional Chinese medicine prepared through a method can be used for inhibiting the ingestion and absorption of an intestinal canal tissue on internal cholesterol by reducing blood fat, inhibiting the synthesis of the internal cholesterol, accelerating the steatolysis, promoting the cholesterol to be transformed into bile acid, reducing the content of the cholesterol and keeping the intestinal tract smooth by moisturizing pathogenic dryness to loosen the bowel.

The invention discloses a method for repairing an eutrophic water body. The method comprises the following steps: 1, preparing an eutrophic water body repairing agent from water, an oxygen release agent, biomass charcoal powder, a composite microbial agent, an alkaline agent and a binder; and 2, applying the eutrophic water body repairing agent to the eutrophic water body. The method for repairingthe eutrophic water body has the advantages of high removal rate, low cost, environmental friendliness and the like, and the eutrophic water body can be efficiently and durably repaired.

The invention discloses a special organic fertilizer for saline and alkaline land. The special organic fertilizer comprises, by weight, 32-36 parts of shaddock peel, 5-13 parts of kochia shoots, 10-20 parts of waste fallen leaves, 8-14 parts of peanut shells, 12-16 parts of asparagus roots, 8-10 parts of benzoin, 4-8 parts of twotooth achyranthes roots, 20-25 parts of morning glories, 7-15 parts of microcotis leaves and 3-7 parts of hairyvein agrimony. The prepared special organic fertilizer is complete in nutrient element and lasting in fertilizer effect and has the functions of increasing fertilizer utilization rate, improving the saline and alkaline land and improving crop quality.

The invention belongs to the technical field of medicine, and relates to a biologically safe antitumor drug sensitizer, and a preparation method and application thereof. The fluorescent carbon quantum dot is prepared by taking sugar as a raw material and oil as a reaction solvent through heating and stirring similar to traditional cooking. Compared with a traditional carbon quantum dot preparation method, the preparation method is simple, time-saving, easy to implement, simple in preparation condition requirement, low in cost and capable of achieving large-scale preparation. The prepared fluorescent carbon quantum dot is uniform in size, stable and adjustable in fluorescence emission, high in water dispersibility, high in safety and good in biocompatibility. Meanwhile, the chemical structural characteristics of the carbon quantum dot are similar to those of glucose, the carbon quantum dot can competitively inhibit glucose uptake of tumor cells, interfere growth and proliferation of the tumor cells, improve the sensitivity of the tumor cells to various antitumor agents and improve the tumor treatment effect, and the carbon quantum dot is a sensitizer for widely enhancing the tumor treatment effect, and can be popularized and applied to combined treatment of various tumors.

The invention relates to a traditional Chinese medicine composition with functions of effectively reducing fat and losing weight as well as increasing immunity, aiming at solving the problems that the traditional weight-reducing medicines are single in function way and obvious in side effects. The traditional Chinese medicine composition is prepared by combining basic theories of Chinese medicine with a modern targeting preparation theory, starts from the three aspects of inhibiting the absorption and utilization of the organism for the fat in food, inhibiting the liver from using glucose to synthesize the fat and inhibiting fat cells from using intake glucose and fatty acids to synthesize the fat, and can inhibit the enlargement of volumes of body fat cells and the increment of number of adipose cells by directly promoting the decomposition of the fat in a human body and indirectly controlling the adipose cells to synthesize the fat, thus cutting off the root causes of obesity by means of the three aspects and two target points; furthermore, by combining the modern medicine, the traditional Chinese medicine composition can be used for carrying out endogenous regulation from the three aspects of promoting the excretion of toxins, stimulating the nervous system and proliferating probiotics in the human body so as to increase the immunity.

The invention relates to an icariin bone-targeting nano-liposome, and a preparation method and an application thereof. The nano-liposome comprises icariin, phosphatidylcholine, cholesterol and a solubilizer according to a mass ratio of (6-20):(100-120):(20-30):(10-80), and the particle size of the nano-liposome is less than 80 nm. The icariin is processed to form the nano-liposome dosage form, andthe particle size is controlled to be less than 80 nm in order to make the nano-liposome have good bone tissue passive targeting ability. The modification effect of bone target makes the nano-liposome have active targeting ability; and the modification effect of a polyethylene glycol derivative makes the nano-liposome have a long-cycle characteristic. The nano-liposome has good targeting ability,can load the icariin to improve the solubility and the absorption problem of the icariin, also can control the in vivo process of the icariin, and has sustained release and controlled release effects.

The invention relates to a production technology of pulp, in particular to a technology for producing amygdalus communis peel pulp by using a compound enzyme. According to the technology, lipase, lysozyme, pectinase, feruloyl esterase, aldolase, laccase, xylanase, arabinose isomerase, cellulase and dextranase are mixed into the compound enzyme, and after amygdalus communis peel is subjected to pulping, the compound enzyme is added, and even stirring and mixing are conducted. Then, chlorine is introduced for chlorination, and the pulp is bleached through sodium hypochlorite, subjected to acid treatment through hydrochloric acid, finally conveyed to a concentrator for concentration and then subjected to pulping through a pulper for obtaining the amygdalus communis peel pulp. The obtained amygdalus communis peel pulp is good in quality, high in viscosity, high in polymerization degree, natural and free of pollution, by adding the compound enzyme, interference of hemicellulose, lignin, pectic substances and the like is avoided, and normal operation of the technology is guaranteed.

The invention provides the application of combining lamivudine and domperidone to prepare sedative medicine. The research of the present invention finds that when lamivudine and domperidone are used in combination in a specific ratio, they can have a definite sedative effect; moreover, the sedative effect is relatively mild and will not cause loss of communication ability or difficulty in awakening. Further studies on pharmacological properties showed that the drug can promote GABA and GABA A Receptor binding increases the opening frequency of chloride ion channels; at the same time, it down-regulates the content of glutamate in the cerebral cortex and hypothalamus of experimental animals, thereby reducing the excitatory neurotoxicity in the brain; moreover, it can selectively bind to 5-hydroxytryptamine 1A receptors and inhibit Synaptic uptake of serotonin leading to upregulation of serotonin levels. Based on the above novel properties found, the present invention determines the new application of lamivudine and domperidone in combination for the preparation of sedative drugs, which not only expands the optional range of sedative drugs, but also improves the sedative effect to a certain extent.

The invention discloses a method for restoring eutrophic water body, which comprises the following steps: 1. The eutrophic water body restoration medicament is prepared by using water, oxygen release agent, biomass charcoal powder, compound bacterial agent, alkali agent and binder. ; Second, the application of chemicals to eutrophic water bodies. The eutrophication water body restoration method of the invention has the advantages of high removal rate, low cost, environmental friendliness and the like, and can efficiently and lastingly restore the eutrophication water body.