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Fluorescent carbon quantum dot, preparation method thereof, and application of fluorescent carbon quantum dot in preparation of antitumor drug sensitizer

An anti-tumor drug and carbon quantum dot technology, applied in the field of medicine, can solve problems such as limited application, toxicity of raw materials, biological safety, and complex synthesis methods

Pending Publication Date: 2021-08-31
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some urgent problems to be solved in the biomedical application of carbon quantum dots currently studied: (1) the raw materials are toxic or have low biological safety, which limits their application in vivo; (2) the synthesis method is complicated and the reaction conditions are relatively strict. There are few green and non-biotoxic methods, which seriously hinder the development of its application; (3) the current research on carbon quantum dots is mainly focused on biological imaging and as a drug carrier, and its further biological effects, especially in tumor treatment The mechanism of carbon dots-biological interaction is unknown, which limits the wide application of carbon quantum dots in cancer therapy

Method used

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  • Fluorescent carbon quantum dot, preparation method thereof, and application of fluorescent carbon quantum dot in preparation of antitumor drug sensitizer
  • Fluorescent carbon quantum dot, preparation method thereof, and application of fluorescent carbon quantum dot in preparation of antitumor drug sensitizer
  • Fluorescent carbon quantum dot, preparation method thereof, and application of fluorescent carbon quantum dot in preparation of antitumor drug sensitizer

Examples

Experimental program
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Effect test

Embodiment 1

[0091] Mix 6g of oil (corn oil, rapeseed oil, peanut oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, canola oil, sunflower oil, soybean oil, sesame oil, grape seed oil, walnut oil and peony seed one or more of oil, etc.) and 3g of sugar (one or more of white granulated sugar, soft white sugar, brown granulated sugar, polycrystalline rock sugar, single crystal rock sugar, cube sugar, borneol sugar and brown sugar, etc.) In a 25mL round-bottomed flask, react in an oil bath at 160°C for 6min. The resulting product is extracted, rotary evaporated and dialyzed to remove residual sugar and oil to obtain eCNDs.

Embodiment 2

[0093] Mix 6g of oil (corn oil, rapeseed oil, peanut oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, canola oil, sunflower oil, soybean oil, sesame oil, grape seed oil, walnut oil and peony seed Oil, etc.) and 3g of sugar (white sugar, soft white sugar, brown sugar, polycrystalline rock sugar, single crystal rock sugar, cube sugar, borneol sugar, brown sugar, etc.) were placed in a 25mL round bottom flask, and reacted in an oil bath at 199°C After 6 minutes, the obtained product was extracted, rotary evaporated and dialyzed to remove residual sugar and oil to obtain eCNDs.

Embodiment 3

[0095] Mix 8g of oil (corn oil, rapeseed oil, peanut oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, canola oil, sunflower oil, soybean oil, sesame oil, grapeseed oil, walnut oil and peony seed oil, etc.) into a 25mL round-bottomed flask and heated to 160°C in an oil bath, then add 3g of sugar (white sugar, soft white sugar, brown sugar, polycrystalline rock sugar, single crystal rock sugar, square sugar, borneol sugar and brown sugar etc.) for 6 minutes, and the obtained product was extracted, rotary evaporated and dialyzed to remove residual sugar and oil to obtain eCNDs.

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Abstract

The invention belongs to the technical field of medicine, and relates to a biologically safe antitumor drug sensitizer, and a preparation method and application thereof. The fluorescent carbon quantum dot is prepared by taking sugar as a raw material and oil as a reaction solvent through heating and stirring similar to traditional cooking. Compared with a traditional carbon quantum dot preparation method, the preparation method is simple, time-saving, easy to implement, simple in preparation condition requirement, low in cost and capable of achieving large-scale preparation. The prepared fluorescent carbon quantum dot is uniform in size, stable and adjustable in fluorescence emission, high in water dispersibility, high in safety and good in biocompatibility. Meanwhile, the chemical structural characteristics of the carbon quantum dot are similar to those of glucose, the carbon quantum dot can competitively inhibit glucose uptake of tumor cells, interfere growth and proliferation of the tumor cells, improve the sensitivity of the tumor cells to various antitumor agents and improve the tumor treatment effect, and the carbon quantum dot is a sensitizer for widely enhancing the tumor treatment effect, and can be popularized and applied to combined treatment of various tumors.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a biologically safe antitumor drug sensitizer, in particular to a fluorescent carbon quantum dot, a preparation method thereof and an application in preparing an antitumor drug sensitizer. The fluorescent carbon quantum dot prepared by the invention has uniform size, stable and adjustable fluorescence emission, high water dispersibility, high safety and good biocompatibility, can competitively inhibit the uptake of glucose by tumor cells, and interfere with the growth of tumor cells Proliferation, improve the sensitivity of tumor cells to various anti-tumor agents, improve the therapeutic effect of tumors, and can be used in the combined treatment of various tumors. Background technique [0002] The prior art discloses that in clinical practice, the normal efficacy of some anti-tumor drugs on tumor sites cannot be fully exerted and has obvious side effects on normal tissues. Theref...

Claims

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Application Information

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IPC IPC(8): C09K11/65B82Y20/00B82Y40/00A61K49/00A61P35/00A61K33/00A61K45/06
CPCC09K11/65B82Y20/00B82Y40/00A61K49/0067A61K45/06A61P35/00A61K33/00A61K49/00A61K47/00G01N21/64C01B32/15A61K31/00
Inventor 黄容琴王义霍涛涛
Owner FUDAN UNIV
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