Ratiometric fluorescent probe for detecting drugs and preparation method thereof

A technology of ratiometric fluorescent probes and drugs, which is applied in the field of ratiometric fluorescent probes for drug detection and its preparation, can solve the problems that the fluorescence emission intensity is easily interfered by external factors, unstable, and the accuracy of detection results is not enough, and it is not easy to achieve The effect of external condition interference, low cost and low price

Active Publication Date: 2020-06-12
ANHUI UNIVERSITY
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Problems solved by technology

In the construction of ratiometric fluorescence sensors based on metal nanoclusters, the early method is to mix two substances with different luminescent properties, but this method will make the fluores

Method used

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  • Ratiometric fluorescent probe for detecting drugs and preparation method thereof
  • Ratiometric fluorescent probe for detecting drugs and preparation method thereof
  • Ratiometric fluorescent probe for detecting drugs and preparation method thereof

Examples

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Example Embodiment

[0037] Example 1

[0038] The ratio fluorescent probe of this embodiment is a three-layer package structure, the inner layer is copper cluster I, the middle layer is a metal organic framework material containing amino groups, and the outer layer is copper cluster II containing carboxyl groups. Copper cluster I and copper The cluster II emits different colors of fluorescence under a single excitation light; the surface of the copper cluster II is modified with antibodies that can specifically bind to the drug to be detected; the metal organic framework material is connected to the copper cluster II through a carboxyl group and an amino group.

[0039] Specifically, in this embodiment: Copper cluster I is a copper nanocluster that emits blue fluorescence with a center wavelength of 450 nm under 365nm excitation light; Copper cluster II is a copper nanocluster that emits a center wavelength of 600nm under 365nm excitation light Orange fluorescent copper nanoclusters; metal organic fra...

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Abstract

The invention discloses a ratiometric fluorescent probe for detecting drugs and a preparation method thereof. The ratiometric fluorescent probe is of a three-layer wrapping structure, the inner layeris a copper cluster I, the middle layer is a metal organic framework material containing amino, the outer layer is a copper cluster II containing carboxyl, and the copper cluster I and the copper cluster II emit fluorescence of different colors under single exciting light. The surface of the copper cluster II is modified with an antibody which can be specifically combined with a drug to be detected; and the metal organic framework material is connected with the copper cluster II through carboxyl and amino. The ratiometric fluorescent probe is high in detection sensitivity, high in reliability, high in signal-to-noise ratio, high in detection flux, simple to operate and capable of effectively detecting the drug content.

Description

technical field [0001] The invention belongs to the field of public health safety detection, and in particular relates to a ratio fluorescent probe for drug detection and a preparation method thereof. Background technique [0002] Drugs are a major problem that seriously threatens human health. Accurate drug detection is of great significance to combating drug crimes, detecting drug cases, and curbing the spread of drugs. In recent years, the soaring drug cases have also put forward higher requirements for drug detection technology. [0003] At present, commonly used drug detection techniques include traditional chromatography, spectroscopy, immunoassay, and electrochemical methods. Although these drug detection methods can meet the needs of anti-drug, anti-drug police and drug rehabilitation institutions in their work to a certain extent, these detection methods require expensive instruments, professional testers, and cumbersome operating steps, which undoubtedly increase ...

Claims

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Application Information

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IPC IPC(8): G01N21/64C09K11/02C09K11/58
CPCG01N21/645C09K11/02C09K11/58
Inventor 杜袁鑫韩梦史宏宇
Owner ANHUI UNIVERSITY
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