Application of lamivudine and domperidone in combination for the preparation of sedative drugs

Abstract

The invention provides the application of combining lamivudine and domperidone to prepare sedative medicine. The research of the present invention finds that when lamivudine and domperidone are used in combination in a specific ratio, they can have a definite sedative effect; moreover, the sedative effect is relatively mild and will not cause loss of communication ability or difficulty in awakening. Further studies on pharmacological properties showed that the drug can promote GABA and GABA A Receptor binding increases the opening frequency of chloride ion channels; at the same time, it down-regulates the content of glutamate in the cerebral cortex and hypothalamus of experimental animals, thereby reducing the excitatory neurotoxicity in the brain; moreover, it can selectively bind to 5-hydroxytryptamine 1A receptors and inhibit Synaptic uptake of serotonin leading to upregulation of serotonin levels. Based on the above novel properties found, the present invention determines the new application of lamivudine and domperidone in combination for the preparation of sedative drugs, which not only expands the optional range of sedative drugs, but also improves the sedative effect to a certain extent.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, and further relates to the new medical application of substances, in particular to the application of lamivudine and domperidone in combination for the preparation of sedative drugs. Background technique [0002] Sedatives are a general term for a large class of drugs that promote calmness and sleep in the human body, and are mainly used for symptomatic treatment of symptoms such as anxiety and irritability in mental disorders. Ideal sedative drugs need to have the following characteristics: 1. Little impact on circulation and respiration; 2. Quick onset and obvious effect; 3. Fast drug metabolism and basically no obvious accumulation effect; 4. Little impact on liver and kidney functions 5. Excellent anti-anxiety and adaptive amnesia effects, easy to wake up when using, and quickly restore consciousness after stopping the drug. Currently, commonly used sedatives mainly include benzo...

AI Technical Summary

Problems solved by technology

In the prior art, no lamivudine or domperidone has been found to have a sedative effect or a central nervous system inhibitory effect on the human body

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