A kind of artificial articular cartilage and preparation method thereof

Abstract

The invention is an artificial articular cartilage, which is characterized in that it is prepared from the following raw materials: polyvinyl alcohol and water, the molecular weight of the polyvinyl alcohol raw material ranges between 1000-1900, and the polyvinyl alcohol and water The feed ratio is 15%~70% (w / v). The resulting product improves the anti-infection ability of the material, reduces the risk of implantation in clinical operations, and significantly improves the comprehensive mechanical properties of the material, including compressive strength, Fatigue resistance and wear resistance, etc.

Description

technical field

[0001] The invention relates to artificial articular cartilage and a preparation method thereof, belongs to the technical fields of medical equipment, biological materials, and medical materials, and is a key material used as articular cartilage replacement for treating arthritis. Background technique

[0002] Arthritis generally refers to inflammatory diseases that occur in human joints and their surrounding tissues and are caused by inflammation, infection, degeneration, trauma or other factors, mainly including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, reactive joints arthritis, gouty arthritis etc. According to statistics, there are more than 100 million arthritis patients in my country, and the number is constantly increasing. Among them, half of the people over the age of 50 suffer from osteoarthritis, and 90% of women and 80% of men over the age of 65 suffer from osteoarthritis. About 10 to 15 years shorter. Arthritis is a disease ...

Examples

Embodiment 1

[0037] Embodiment 1 A kind of preparation method of artificial articular cartilage, the steps are as follows:

[0038] (1) Take 20g of polyvinyl alcohol raw material (the average degree of polymerization is between 1000 and 1900), add it to 100mL of water, heat it to 95°C, stir it mechanically, control the stirring speed at 300r / min, and stir it at a constant temperature under reflux for 6 hours. After the vinyl alcohol is completely dissolved, the solution is a transparent viscous liquid;

[0039] (2) Then turn off the heating, cool naturally to 60°C, stop stirring, let it stand for 2 hours, then pour the slime into the mold, quickly place it in a -20°C environment and freeze it for 16 hours, and then heat up at a rate of 5°C / h to -5°C, then raise the temperature to 5°C at a rate of 1°C / h, hold for 2 hours, then raise the temperature to 25°C at 5°C / h, and hold for 2 hours, thus completing a freeze-thaw self-assembly process, repeat this process process 5 times, and then cros...

Embodiment 2

[0040] Embodiment 2 Change the addition of polyvinyl alcohol and water to be 20g and 80ml respectively, all the other conditions remain unchanged, repeat the test according to the experimental conditions mentioned in Example 1, repeat the test, the sample number is marked as 2-02;

Embodiment 3

[0041] Embodiment 3 Change the addition of polyvinyl alcohol and water to be 40g and 100ml respectively, all the other conditions remain unchanged, repeat the test according to the experimental conditions mentioned in Example 1, repeat the test, and the sample number is marked as 2-03;

technical field

[0001] The invention relates to artificial articular cartilage and a preparation method thereof, belongs to the technical fields of medical equipment, biological materials, and medical materials, and is a key material used as articular cartilage replacement for treating arthritis. Background technique

[0002] Arthritis generally refers to inflammatory diseases that occur in human joints and their surrounding tissues and are caused by inflammation, infection, degeneration, trauma or other factors, mainly including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, reactive joints arthritis, gouty arthritis etc. According to statistics, there are more than 100 million arthritis patients in my country, and the number is constantly increasing. Among them, half of the people over the age of 50 suffer from osteoarthritis, and 90% of women and 80% of men over the age of 65 suffer from osteoarthritis. About 10 to 15 years shorter. Arthritis is a disease ...

Examples

Embodiment 1

[0037] Embodiment 1 A kind of preparation method of artificial articular cartilage, the steps are as follows:

[0038] (1) Take 20g of polyvinyl alcohol raw material (the average degree of polymerization is between 1000 and 1900), add it to 100mL of water, heat it to 95°C, stir it mechanically, control the stirring speed at 300r / min, and stir it at a constant temperature under reflux for 6 hours. After the vinyl alcohol is completely dissolved, the solution is a transparent viscous liquid;

[0039] (2) Then turn off the heating, cool naturally to 60°C, stop stirring, let it stand for 2 hours, then pour the slime into the mold, quickly place it in a -20°C environment and freeze it for 16 hours, and then heat up at a rate of 5°C / h to -5°C, then raise the temperature to 5°C at a rate of 1°C / h, hold for 2 hours, then raise the temperature to 25°C at 5°C / h, and hold for 2 hours, thus completing a freeze-thaw self-assembly process, repeat this process process 5 times, and then cros...

Embodiment 2

[0040] Embodiment 2 Change the addition of polyvinyl alcohol and water to be 20g and 80ml respectively, all the other conditions remain unchanged, repeat the test according to the experimental conditions mentioned in Example 1, repeat the test, the sample number is marked as 2-02;

Embodiment 3

[0041] Embodiment 3 Change the addition of polyvinyl alcohol and water to be 40g and 100ml respectively, all the other conditions remain unchanged, repeat the test according to the experimental conditions mentioned in Example 1, repeat the test, and the sample number is marked as 2-03;

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