The invention discloses a production method for a low-alloy medium-thickness steel plate. The low-alloy medium-thickness steel plate comprises, by weight, 0.10%-0.18% of C, 0.15%-0.55% of Si, 1.20%-0.88% of Mn, 0.01%-0.02% of P, 0-0.020% of S, 0.015%-0.050% of Al, 0.28%-0.41% of Ni, 0.04%-0.12% of V and the balance Fe and impurity elements. According to the production method for the low-alloy medium-thickness steel plate, the requirements for the manufacturing industry are met, and the ideas of energy saving, consumption reducing and environment-friendly steel are achieved. The low-alloy medium-thickness steel plate has the characteristics that the alloy content is decreased, center segregation is reduced, and the performance uniformity is improved; the carbon equivalent is decreased, and the welding performance is improved; compared with the performance of a steel plate produced through a traditional method, the performance of the steel plate is greatly improved; some of processes are avoided, the alloy content is decreased, direct hot charging is conducted after continuous casting, and the production cost is reduced; the cost is low, the performance is high, and the welding performance is good.