The invention provides integrated sewage harmless equipment, and belongs to the technical field of sewage and sludge treatment. The equipment comprises a flow meter, a valve, an ultrasonic/ultraviolet reaction tank, a flow guide partition plate, an ultraviolet lamp UVC, an overflow water outlet pipe, an emptying port I, an overflow water tank, a secondary treatment water inlet control valve, an ultrasonic/photocatalytic reaction tank, a flow guide partition plate loaded with a photocatalyst, a flow guide partition plate slot, a photocatalytic light source UVA, a water outlet, an emptying port II and an ultrasonic transducer. Under the combined action of ultrasonic waves, ultraviolet rays and photocatalytic reaction, multiple purposes of inactivation of pathogenic microorganisms in sewage, degradation of antibiotics and resistant genes of the antibiotics and the like are achieved, and harmless treatment of the sewage is achieved. The technology can greatly reduce the risk of by-products caused by chemical agent disinfection, is simple to operate, does not need auxiliary equipment and facilities, is safe and efficient, and is especially suitable for harmless treatment of secondary effluent of a sewage treatment plant, biogas slurry and sewage with similar properties.