The invention discloses a drug composition of traditional Chinese medicine for detoxification and a preparation method thereof. The composition is prepared from the following medicines in parts by mass: 2-20 parts of Jinbuhuan, 3-40 parts of Albizia Julibrissin, and 3-40 parts of Albizia Julibrissin , 2‑40 parts of Tribulus terrestris, 2‑20 parts of American ginseng, 1‑10 parts of Chinese herb, 2‑20 parts of angelica, 2‑20 parts of jujube seed, 2‑20 parts of Cortex Phellodendri, 1‑10 parts of Coptis chinensis, 2‑20 parts of Corydalis 2‑20 , 1‑10 parts of tangerine peel, 2‑20 parts of Bupleurum, 2‑20 parts of Cimicifuga, 1‑10 parts of roasted licorice, 1‑10 parts of agarwood, 1‑10 parts of Chuan Fritillaria and 1‑10 parts of amber; , Chuan Fritillaria and amber are ground, sieved, and packed into capsules, and other raw materials are decocted into decoction, and the decoction and capsules are taken together; the medicine of the present invention has the effects of relieving depression, calming the nerves, and analgesia, and can reduce the procrastination of drug addicts. Symptoms, reduce the probability of relapse, promote the physical and mental health of drug addicts, and reduce social and family burdens.