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Producing raw material containing benzyl carbinol glycosides from Cistanche deserticola by using membrane separation technique and preparation method thereof

A technology for separation of phenylethanol glycosides, which is applied in the field of raw materials containing phenylethanol glycosides and its preparation, can solve the problems of phenylethanol glycosides in Cistanche deserticola, large solvent consumption, long production cycle, etc., and reduce concentration and drying time, shorten the extraction time, reduce the effect of increased production cost

Inactive Publication Date: 2009-06-24
HETIAN DCM MEDICINE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method consumes a lot of solvent, has high cost, long production cycle, relatively low yield, and there are certain safety hazards.
At present, there is no research report on the application of membrane separation technology to extract and separate phenylethanol glycosides in Cistanche deserticola

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Take the dried fleshy stem of Cistanche tubulosa from which impurities have been removed, cut into small pieces, and pulverize through a sieve with an aperture of 840 μm as a raw material for processing;

[0039] 2. Use ethanol with a concentration of 70% as a solvent, and use 18 times the weight of the processed raw material of Cistanche to extract the processed raw material of Cistanche under reflux for 2 hours, and then use 8 times the amount of 70% ethanol for reflux extraction twice, each time for 1 hour;

[0040] 3. Combine the above extracts, concentrate under reduced pressure to a relative density of 1.08, put them in a centrifuge and centrifuge at 5000 rpm for 0.3 hours, and collect the supernatant;

[0041] 4. Filtrate through a microfiltration alumina ceramic membrane with a pore size of 0.25 μm, operate at a pressure of 0.3 MPa, and a temperature of 25 ° C to remove sub-particles, particles, flocculent precipitates and most microorganisms;

[0042] 5. Fil...

Embodiment 2

[0046] 1. Take the dried saline Cistanche fleshy stems removed from impurities, and crush them through a 420 μm aperture sieve;

[0047] 2. Use water as the solvent, and use 10 times the weight of the processed raw materials of Cistanche to extract the processed raw materials of Cistanche by ultrasonic extraction for 40 minutes at an ultrasonic frequency of 20KHz, pour out the supernatant as the extraction solution, and then use 6 times the amount of solvent to repeat the extraction 2 times, 30 minutes each time;

[0048] 3. The extracts obtained in step 2 were combined, concentrated under reduced pressure to a relative density of 1.05, placed in a centrifuge at 3000 rpm, centrifuged for 0.5 hours, and the permeate was collected;

[0049] 4. Take the permeate from step 3 and filter it through a microfiltration alumina ceramic membrane with a pore size of 0.10 μm, operating at a pressure of 0.4 MPa and at a temperature of 20 °C;

[0050] 5. Take the permeate from step 4 and fi...

Embodiment 3

[0054] 1. Take 200 parts by weight of the dry desert desert cistanche fleshy stems removed from impurities, and pulverize through a 1mm aperture sieve;

[0055] 2. Use water as the solvent, and use 12 times the weight of the processed raw materials of Cistanche to extract the processed raw materials of Cistanche by ultrasonic extraction for 40 minutes at an ultrasonic frequency of 40KHz, pour out the supernatant as the extraction solution, and then use 5 times the amount of solvent to repeat the extraction 3 times, 30 minutes each time;

[0056] 3. Combine the extracts obtained in step 2, concentrate under reduced pressure to a relative density of 1.05, place them in a centrifuge at 10,000 rpm for 0.2 hours, and collect the permeate;

[0057] 4 Filter the permeate obtained in step 3 through a microfiltration antimony oxide ceramic membrane with a pore size of 0.10 μm, and the operating pressure is 0.5 MPa;

[0058] 5. Filter the permeate obtained in step 4 through an ultrafil...

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Abstract

The present invention relates to a raw material containing phenylethanol glycoside produced from Cistanche deserticola by applying membrane separation technology and a preparation method thereof. The raw material containing phenylethanol glycoside obtained from Cistanche deserticola in the present invention contains verbascoside > 40%, and the preparation method mainly includes Material selection, extraction, microfiltration, ultrafiltration, nanofiltration, drying and other processes. Compared with the prior art, the transfer rate of the active ingredients extracted from Herba Cistanche by the method of the present invention has been greatly improved, while the dry paste yield has been reduced to a certain extent, and the active ingredients in Herba Cistanche have been effectively enriched , under the premise of not changing the structure of the active ingredient, the extraction rate of the active ingredient is improved, the production cost is saved, and the process cycle is shortened.

Description

technical field [0001] The invention relates to a raw material containing phenylethanol glycoside produced from Cistanche deserticola and a preparation method thereof, in particular to a raw material containing phenylethanol glycoside produced from Cistanche deserticola and a preparation method thereof. Background technique [0002] Herba Cistanches, a traditional Chinese medicine, is the dry fleshy stem with scaly leaves of Cistanche Hoffmg.Et Link, a plant of the genus Cistanche in the family Orobanchaceae. Efficacy, is a famous tonic Chinese medicine. It has the highest frequency of occurrence in the prescriptions for nourishing kidney and yang in the past dynasties, and its probability in anti-aging and anti-aging traditional Chinese medicine prescriptions is second only to ginseng, so it is also called "desert ginseng". Because of its definite curative effect, mild medicinal properties, nourishing but not harsh, and nourishing but not dry, Cistanche is widely used in C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18A61K36/64A61K125/00
Inventor 黄利兴胡君萍杨建华杨军波
Owner HETIAN DCM MEDICINE BIOLOGICAL TECH
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