Ophthalmic gel and its preparation method

A technology of ophthalmic gel and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine ophthalmic gel and its preparation, which can solve the problems of weak eye irritation and difficulty of excipients, and achieve the effect of strong antibacterial effect, fast onset and increased viscosity

Active Publication Date: 2007-08-01
TEYI PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the eyes of the human body are weak in tolerance to external stimuli, and it is difficult for general excipients to meet the requirements of being used as a viscosity enhancer for the eyes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Table 1

[0020]

[0021] As shown in Table 1: get bear bile powder, add 100g water for injection, heat and boil for 10 minutes to dissolve, let cool, add ethanol to make the alcohol content reach 75%, stand for 24 hours, filter, and the filtrate reclaims ethanol; Borax, boric acid, sodium chloride, ethyl p-hydroxybenzoate, add 800g water for injection, heat and boil to dissolve, filter, let cool, add sodium hyaluronate, soak, stand for several hours, stir well, and recover ethanol After mixing the liquid medicine, add water for injection to the prescribed amount, stir well, and pack it.

Embodiment 2-4

[0023] Table 2

[0024] Element

[0025] As shown in table 2: get bear bile powder, sodium chloride, add 100g water for injection to ethyl p-hydroxybenzoate, heat and boil for 10 minutes to dissolve, let cool, add ethanol to make the alcohol content reach 75%, let stand for 24 hours , filter, and the filtrate recovers ethanol; take another 800g water for injection, add sodium hyaluronate, soak it, let it stand for several hours, stir well, mix it with the liquid medicine after recovering ethanol, add water for injection to the specified amount, stir well, and divide Pack. The above process is carried out under sterile conditions.

Embodiment 5-7

[0027] table 3

[0028]

[0029] As shown in Table 3: take sodium chloride, add about 80% water for injection, heat and boil to dissolve, filter, let cool, add sodium hyaluronate, soak, stand for several hours, and stir well. The borneol and benzyl alcohol are dissolved in an appropriate amount of ethanol, slowly stirred and added to the above-mentioned matrix, the pearl liquid is added to the mixture, and the water for injection is supplemented to a prescribed amount, stirred evenly, and then packaged.

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PUM

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Abstract

The invention relates to an eye gel which comprises base material, reactive Chinese medicinal components, auxiliary material and water by a mass ratio of 0.05-10.0:0.1- 40.0:1-14:50-98. The gel is capable of increasing viscosity of the active Chinese medicinal constituents, raising the retention period of the medicament in eyes, and reducing medicinal loss.

Description

technical field [0001] The invention relates to an ophthalmic medicine and a preparation method thereof, in particular to a traditional Chinese medicine ophthalmic gel and a preparation method thereof. Background technique [0002] Traditional Chinese medicine is the quintessence of our country. It has few side effects and a wide variety of raw materials. Moreover, traditional Chinese medicine has a long history of treating eye diseases and has many classic drugs. But at present, there are few varieties of traditional Chinese medicine ophthalmic preparations on the market in my country, and new varieties are even rarer. Compared with foreign and joint ventures in western medicine research, domestic manufacturers are far behind in the research, extraction and formulation improvement of active ingredients of traditional Chinese medicine. At present, the preparation forms of Chinese patent medicines for treating eye diseases mainly include eye drops, eye drops, etc. Their main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/36A61P27/02
Inventor 尚红鹰
Owner TEYI PHARMACEUTICAL GROUP CO LTD
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