Medicinal composition containing lamiophlomis and Touhualiao

A composition and technology of Polygonum cephalus, which are applied in the field of medicine to achieve better bacteriostatic effect, reduce the permeability of abdominal capillaries, and ensure safety.

Inactive Publication Date: 2010-05-12
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Using the interaction of Polygonum cephalosporin and Duyiwei to prepare medicines for treating diseases such as pyelonephritis, cystitis, and urinary calculi with compatible prescriptions, there has not been any report yet

Method used

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  • Medicinal composition containing lamiophlomis and Touhualiao
  • Medicinal composition containing lamiophlomis and Touhualiao
  • Medicinal composition containing lamiophlomis and Touhualiao

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Example 1 Preparation, Identification and Content Determination of Polygonum cephalosporin Extract

[0169] Preparation of Polygonum cephalica Extract

[0170] Take Polygonum cephalosporin, chop it, add water to decoct twice, each time for 2 hours, filter, concentrate the filtrate under reduced pressure to a relative density of 1.10-1.15, let it cool, add ethanol to make the alcohol content to 60%, and refrigerate for 24 hours , filtered, and the filtrate recovered ethanol until it had no alcohol smell, and added it to the treated polyamide column (30-60 mesh, ethanol wet packing, pre-washed with an appropriate amount of ethanol, and then washed with water until it had no alcohol smell, and set aside). First wash with 2 times column volume of water, then wash with 2 times column volume of 10% ethanol, discard the washing solution, and then elute with 3 times column volume of 70% ethanol, collect the eluate, recover the ethanol and concentrate it into The concentrated...

Embodiment 2

[0187] Example 2 Preparation, Identification and Content Determination of Unique Flavor Extract

[0188] Preparation of Duyiwei Extract

[0189] Take 100kg of unique herbs, crush them, add water to decoct twice, each time for 2 hours, filter, the filtrate is concentrated into a dilute extract with a relative density of 1.03-1.08, and add the dilute extract to the treated macroporous resin (D101 type, wet packed column with ethanol, pre-washed with appropriate amount of ethanol, and then washed with water until there is no alcohol smell, set aside), first rinse with 2 times the column volume of water, then rinse with 2 times the column volume of 20% ethanol, discard Remove the flushing solution, then elute with 3 times column volume of 80% ethanol, collect the eluent, recover the ethanol and concentrate to a concentrated solution with a relative density of 1.08-1.12, and spray dry to obtain the product.

[0190] Identification of unique extract

[0191] Take 50mg of Duyiwei...

Embodiment 3

[0205] Example 3 Preparation of aqueous injection of the pharmaceutical composition of the present invention

[0206] prescription:

[0207] Polygonum cephalosporin extract 115g (equivalent to 10kg of the original medicinal material of Polygonum cephalum)

[0208] Duyiwei extract 48g (equivalent to 5kg of Duyiwei original medicinal material)

[0209] Add water for injection to 10000ml

[0210] A total of 1000 sticks were prepared

[0211] Preparation Process:

[0212] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0213] 2) Take water for injection with a dosing volume of 80%, add the prescribed volume of Polygonum cephalosporin extract and Duyiwei extract, heat and stir to dissolve completely.

[0214] 3) Add water for injection to the full amount.

[0215] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0216] 5) Decar...

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PUM

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Abstract

A composite medicine in the form of injection, or orally taken liquid or solid for treating pyelonephritis, cystitis and urethral calculus is prepared from 2 Chinese-medicine materials including common lamiophlomis herb, etc.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition prepared from Polygonum cephalica or its extract and Duyiwei or its extract, as well as its preparation method and application. 【Background technique】 [0002] Polygonum capitatum, also known as Sijihong and Shimangcao, is the whole herb of Polygonum capitatum Ham ex D.Don, a plant of the Polygonaceae family. It is distributed in southwest my country and is a commonly used medicine in ethnic minority areas. Polygonum cephalum has the effects of dispelling blood stasis, clearing away heat and detoxification, diuresis and treating stranguria. The white blood cells and red blood cells in the urine of the pyelonephritis model can significantly reduce the mortality of E. coli-infected mice, and reduce the body temperature of febrile rabbits. [0003] Duyiwei is the whole herb of Lamiophlomis rotate (Benth) Kudo, also known as Dubutong, also known as "Dab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/70A61K36/53A61P13/00
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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