Composition containing rhus chinensis for treating cardiovascular diseases and its preparation

A composition and a technology of sapwood can be used in cardiovascular system diseases, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as difficulty in preparing dripping pills

Inactive Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The raw materials used Salvia miltiorrhiza 97g, Panax notoginseng 79g, Salvia sylvestris 35g, Dalbergia oil 3g, and ginseng 40g

[0067] Salvia miltiorrhiza, Panax notoginseng, Salophyllum japonicum and people add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time. Add 4 times the amount of water, decoct for 1 hour, filter, discard the filter residue, and combine the filtrate . The filtrate was concentrated under reduced pressure until the ratio of the volume (L) to the weight of the medicinal material (Kg) was 1:0.9~1.1, and ethanol was added to make the medicinal solution have an alcohol concentration of 70%, stand, filter, and concentrate the filtrate to obtain a relative density of 1.32 ~ 1.40 (55 ℃) extract. Add dalbergia oil, dry, make granules, press into tablets, or coat with sugar, and get ready.

Embodiment 2

[0069] Salvia 100g, Panax notoginseng 10g, Salophyllum 15g;

[0070] Salvia miltiorrhiza, Panax notoginseng and Salvia sylvestris are extracted with 70% ethanol, and the extract is subjected to microfiltration with ceramic membranes to collect the filtrate; the filtrate is ultrafiltration and the operating conditions of the ultrafiltration process are: the inlet pressure of the ultrafiltration is 0.35Mpa, The filtered outlet pressure is 0.20kPa lower than the inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; during the ultrafiltration process, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the material liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating flow or unstable flow in the membrane channel. The flow rate fluctuation difference is 2.0m / s. Nitrogen is intermittently introduced...

Embodiment 3

[0073] The raw materials: Danshen 20g, Panax notoginseng 2g, Salocarpus 10g, Angelica 100g, and Borneol 2.2g.

[0074] Salvia miltiorrhiza, panax notoginseng, saponaria and angelica add 5 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time. Add 4 times the amount of water, decoct for 1 hour, filter, discard the filter residue, and combine the filtrate . The filtrate was concentrated under reduced pressure until the ratio of the volume (L) to the weight of the medicinal material (Kg) was 1:0.9~1.1, and ethanol was added to make the medicinal solution contain an alcohol concentration of 70%, stand, filter, and concentrate the filtrate to obtain a relative density of 1.32 ~ 1.40 (55 ℃) extract. The extract and borneol are fluidized with lactose in an intermittent fluidized bed, and dried to form granules, which are then obtained.

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, Chinese sumac, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

Description

Technical field [0001] The invention relates to a medicinal composition for treating cardiovascular diseases with a salt-containing phylloxera and preparations thereof, in particular to a medicinal composition for treating cardiovascular diseases prepared from Chinese medicinal materials as raw materials. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural or urban areas. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in our country. After 1970, they rose to the second and third places. Cardiovascular and cerebrovascular diseases accounted for the first cause of all deaths. The proportion of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122
Inventor 李旭郑永锋李永强
Owner TIANJIN TASLY PHARMA CO LTD
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