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Composition containing radix paeoniae rubrathe for treating cardiovascular diseases and its preparation

The technology of a composition and preparation is applied in the field of compositions and preparations containing red peony for treating cardiovascular diseases, and can solve the problems of difficulty in preparing dripping pills and the like

Active Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The raw materials are 97g of Salvia miltiorrhiza, 79g of notoginseng, 35g of red peony, 3g of balsamic oil, and 40g of ginseng

[0067] Salvia miltiorrhiza, Panax notoginseng, Radix Paeoniae Rubra and Ginseng 5 times the amount of water, decocted for 2 hours, filtered, and the filter residue was extracted for the second time, added 4 times the amount of water, decocted for 1 hour, filtered, discarded the filter residue, and combined the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. Add balsamic oil, dry, make granules, compress into tablets, or coat with sugar, that is to say.

Embodiment 2

[0069] Danshen 100g, Panax notoginseng 10g, Radix Paeoniae Rubra 15g;

[0070] Salvia miltiorrhiza, Panax notoginseng and Radix Paeoniae Rubra are extracted with 70% ethanol, and the extract is micro-filtered with a ceramic membrane to collect the filtrate; the filtrate is ultra-filtered, and the operating conditions of the ultra-filtration process are: The liquid outlet pressure is 0.20kPa lower than the liquid inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m / s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liq...

Embodiment 3

[0073] Raw material Danshen 20g, Panax notoginseng 2g, Radix Paeoniae Rubra 10g, Angelica sinensis 100g, Borneol 2.2g.

[0074] Add 5 times the amount of water to Danshen, Panax notoginseng, Radix Paeoniae Rubra and Angelica, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. The extract and borneol are fluidized with lactose in a batch fluidized bed, dried, and made into granules.

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, notoginseng, red peony root, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

Description

technical field [0001] The invention relates to a medicinal composition containing red peony root for treating cardiovascular diseases and a preparation thereof, in particular to a medicinal composition for treating cardiovascular diseases made from traditional Chinese medicinal materials. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in my country, and rose to second and third respectively after 1970. Cardiovascular and cerebrovascular diseases accounted for the first of all causes of death. In my country, the proportion of deaths due to cardiovascular and cerebrovascular diseases to the total death population has risen from 12.07% in 1957 to 42.6% in 2001...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122
Inventor 李旭郑永锋李永强
Owner TIANJIN TASLY PHARMA CO LTD
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