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Chitosan compositions

A composition, chitosan technology, applied in the direction of drug combination, tissue regeneration, surgical adhesives, etc.

Inactive Publication Date: 2008-01-02
CARBGRAFT AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The present invention addresses the problems associated with chitosan materials, and their use in applications such as orthopedic

Method used

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  • Chitosan compositions
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Examples

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Embodiment

[0058] The following materials were used in the examples unless otherwise stated:

[0059] Chitosan was purchased from Primex, Norway, 145 kD, and 85% N-deacetylation degree. Chitosan with a lower degree of N-deacetylation was generally prepared according to the principles disclosed in: Sannan T, Kurita K, Iwakura Y. Studies on Chitin, 1. Die Makromolekulare Chemie 1975; 0:1191- 5. Sannan T, Kurita K, Iwakura Y. Studies on Chitin, 2. Makromol. Chem. 1976; 0:3589-600, Guo X, Kikuch, Matahira Y, Sakai K, Ogawa K. Watersoluble Chitin of low degree of deacetylation . Journal of Carbohydrate chemistry 2002;21:149-61 and WO03011912. Hyaluronic acid was purchased from Pharmacia, glycerin was purchased from Fluka, Germany, NaCl was purchased from Merck, MgCl 2 Available from Merck, HCl from Merck, Water millipore.

example 1

[0061] 4 g of chitosan (degree of N-deacetylation 85%, MW 145 kD) were dissolved in 133 g of water and the pH was adjusted to 4.5 with dilute HCl. To the stirred chitosan solution was added an aqueous solution of 12 g NaCl dissolved in 50 g water. The gel-like paste was then spread on a flat plastic surface and air-dried to provide a crispy residue which was further ground into particles (250 μm). The particles were then neutralized in alkaline buffer and washed extensively with water in order to obtain a salt-free porous chitosan matrix. After drying, 0.3 g of porous particles were added to a gel (1.2 g) consisting of 4% chitosan (degree of N-deacetylation 85%, 145 kD) pH 4.5, and 0,4 g glycerol. The paste was allowed to expand for 2 minutes at room temperature, spread out on a flat plastic surface, and formed into a flat plate shape (20x20x2 mm). After drying at 40° C., a firm plate with less elasticity was obtained.

example 2

[0063]3 g of chitosan (degree of N-deacetylation 50%, MW 200 kD) were dissolved in 134 g of water and the pH was adjusted to 4.5 with dilute HCl. To the stirred chitosan solution was added a 50 g aqueous solution of 12 g NaCl and 0.3 g hyaluronic acid. The gel-like paste was dispersed on a flat plastic surface and air-dried to dryness, and ground into particles (250 μm). The granules are then neutralized, washed with water, dried and ground into granules. 0.3 g of the dried porous particles were then thoroughly mixed with 1.2 g of a 4% chitosan solution / gel, pH 4.5 (degree of N-deacetylation 50%, MW 200 kD) to provide a paste. The paste was allowed to swell at room temperature for 2 minutes and molded by filling the paste into tubes to form sticks. Freeze drying of the filled tube and subsequent removal of the tube yielded a firm porous rod containing the chitosan / hyaluronic acid complex.

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Abstract

This invention relates to an orthopaedic composition comprising porous chitosan particles suspended in a liquid medium wherein the liquid medium further comprises a biocompatible polymer. The invention also provides a process for preparing a solid or semi-solid orthopaedic material by drying the orthopaedic composition. The resulting solid or semi-solid orthopaedic material finds use as a bone-replacement material, a bone cement and a tissue scaffold. A process for preparing suitable porous chitosan particles for the present invention by incorporating a porogen capable of inducing crystallinity is also described.

Description

field of invention [0001] The present invention relates to chitosan compositions, especially compositions for orthopedic use. Background of the invention [0002] Bone substitutes are used in a variety of situations such as fracture repair, correction with implants, gap filling after tumor and cyst removal, and in the spine. The older, still active population largely constitutes the increasing number of surgical procedures requiring bone substitutes. Years ago, orthopedic surgeons used the patient's own bone (autograft) for most transplants, but today professionals rely more on cadaver bone (allograft), which can be obtained from commercial bone banks obtained or recovered from the hospital. The reliance on allografts has two disadvantages. First, there is the risk of viral contamination, although this risk is small, expensive testing methods must be used to ensure patient safety. Second, demand for allogeneic products exceeds supply. Combining the above factors, it pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L24/00A61L27/20A61L24/08A61L27/56
CPCA61L24/0036A61L24/0094A61L27/56A61L27/20A61L27/48A61L24/08A61L2430/02A61P19/00C08L5/08A61L24/00
Inventor M·安德森
Owner CARBGRAFT AB
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