Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition containing fbpase-inhibiting agent

A composition and inhibitor technology, applied in the field of pharmaceutical compositions containing FBPase inhibitors, can solve the problems of unknown significant improvement of pancreatic β-cell function and other issues

Inactive Publication Date: 2008-01-30
DAIICHI SANKYO CO LTD
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the significant improvement in pancreatic β-cell function in diabetic patients by the combined use of insulin sensitizers and FBPase inhibitors is completely unknown

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing fbpase-inhibiting agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0061] The FBPase inhibitory activity of the test compound can be determined according to the method of International Publication No. WO00 / 14095. 2-Amino-5-isobutyl-4-{2-[5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphonamido]furyl}thiazole (compound A) It can be prepared according to the method of International Publication No. WO01 / 47935.

[0062] Insulin sensitizer 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione hydrochloride ( Compound B) can be produced according to the methods described in JP-A-9-295970, EP-0745600, USP-5886014 and WO00 / 71540.

[0063] Insulin sensitizer 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)-2,4-thiazole Alkanediones (troglitazone; compound T) can be produced according to the methods of US Patent No. 4,572,912 and Japanese Patent Publication No. Hei 2-31079.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A pharmaceutical composition containing an FBPase inhibitor and an insulin sensitizer which is 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione or a pharmacologically acceptable salt thereof; and a method for preventing or treating diabetes mellitus by administering the composition to a human.

Description

technical field [0001] The present invention relates to the combination of FBPase inhibitor and insulin sensitizer 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2, 4-diketone or its pharmacologically acceptable salt combination is used for diabetes, hyperglycemia, impaired glucose tolerance, obesity, diabetic complications (such as retinopathy, cataract, kidney disease, peripheral nerve disorder, etc.), steroid A pharmaceutical composition for the treatment or prevention of diabetes mellitus, glycogen disease, surgical diabetic-like disease, glycotoxicity, pancreatic β-cell failure, etc. (preferably diabetes, diabetic complications, glycotoxicity, pancreatic β-cell failure). [0002] The present invention also relates to the application of the above-mentioned compound in the preparation of the above-mentioned pharmaceutical composition of the present invention, or the method of preventing or treating the above-mentioned diseases in which the above-me...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K31/664A61K45/00A61P3/10A61P43/00
CPCA61K31/664A61K31/427A61K45/06A61P3/10A61P43/00A61K2300/00A61K45/00
Inventor 吉田大志奥野晃
Owner DAIICHI SANKYO CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com