Pharmaceutical composition containing fbpase-inhibiting agent

A composition and inhibitor technology, applied in the field of pharmaceutical compositions containing FBPase inhibitors, can solve the problems of unknown significant improvement of pancreatic β-cell function and other issues

Inactive Publication Date: 2008-01-30
DAIICHI SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the significant improvement in pancreatic β-cell function in diabetic patients by the combined use of insulin sensitizers and FBPase inhibitors is completely unknown

Method used

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  • Pharmaceutical composition containing fbpase-inhibiting agent

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Experimental program
Comparison scheme
Effect test

Embodiment

[0061] The FBPase inhibitory activity of the test compound can be determined according to the method of International Publication No. WO00 / 14095. 2-Amino-5-isobutyl-4-{2-[5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphonamido]furyl}thiazole (compound A) It can be prepared according to the method of International Publication No. WO01 / 47935.

[0062] Insulin sensitizer 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione hydrochloride ( Compound B) can be produced according to the methods described in JP-A-9-295970, EP-0745600, USP-5886014 and WO00 / 71540.

[0063] Insulin sensitizer 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)-2,4-thiazole Alkanediones (troglitazone; compound T) can be produced according to the methods of US Patent No. 4,572,912 and Japanese Patent Publication No. Hei 2-31079.

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Abstract

A pharmaceutical composition containing an FBPase inhibitor and an insulin sensitizer which is 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione or a pharmacologically acceptable salt thereof; and a method for preventing or treating diabetes mellitus by administering the composition to a human.

Description

technical field [0001] The present invention relates to the combination of FBPase inhibitor and insulin sensitizer 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2, 4-diketone or its pharmacologically acceptable salt combination is used for diabetes, hyperglycemia, impaired glucose tolerance, obesity, diabetic complications (such as retinopathy, cataract, kidney disease, peripheral nerve disorder, etc.), steroid A pharmaceutical composition for the treatment or prevention of diabetes mellitus, glycogen disease, surgical diabetic-like disease, glycotoxicity, pancreatic β-cell failure, etc. (preferably diabetes, diabetic complications, glycotoxicity, pancreatic β-cell failure). [0002] The present invention also relates to the application of the above-mentioned compound in the preparation of the above-mentioned pharmaceutical composition of the present invention, or the method of preventing or treating the above-mentioned diseases in which the above-me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61K31/664A61K45/00A61P3/10A61P43/00
CPCA61K31/664A61K31/427A61K45/06A61P3/10A61P43/00A61K2300/00A61K45/00
Inventor 吉田大志奥野晃
Owner DAIICHI SANKYO CO LTD
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