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Complete water type thin film coating pre-mixture for traditional Chinese medicine tablets
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A technology of film coating and traditional Chinese medicine tablets, which is applied in drug delivery, pharmaceutical formulations, plant/algae/fungus/moss components, etc. It can solve the problems of reinforcement, moisture resistance and heat deformation, and achieve a wide range of moisture-proof properties. Enhanced effect
Active Publication Date: 2012-05-23
上海新菲尔生物制药工程技术有限公司
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[0015] Compared with the prior art, the beneficial effects of the present invention are: solve the problem of special formulations of traditional Chinese medicine preparations in moisture-proof and thermal deformation, screen out a variety of film-forming polymer materials, and add a variety of additives at the same time, changing the formulation The physical film properties of the substance make the film coating material more suitable for a wider range, and the moisture resistance performance is significantly enhanced
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[0026] The application of the present invention, especially on the Chinese medicine tablet, shows the following advantages:
[0027] 1. It solves the disadvantages of insufficient moisture-proof ability of the original film coating material on the traditional Chinese medicine tablet and shortened shelf life of the preparation.
[0028] Using the present invention, the ability of the tablet to isolate water is significantly enhanced. Depend on figure 1 , figure 2 , image 3 It can be seen that the TF-NMP and EMP series film coating premixes of the present invention are obviously better than the imported similar varieties in the moisture-proof effect of the tablet, and the finished product coated with the whole extract of traditional Chinese medicine wrapped by it, under ordinary packaging conditions, after three Years of stability investigation...
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Abstract
The present invention relates to a whole water-typed film coating premixed agent of a traditional Chinese medicine tablet, which comprises the hydroxy propyl methylcellulose, the polyvinyl alcohol, the polyvinyl pyrolidone and acetic ether copolymer, the Polyethylene Glycol 6000, the chalk, the titanium pigment, the coloring agent, others, the plasticizer, the surface acting agent, the assistant for color stabilizer. The other agent belongs to the chewing agent and the suspending agent, the preparation portion of which are the hydroxy propyl methylcellulose, 15 percent to 25 percent; the polyvinyl alcohol, 10 percent to 30 percent; the polyvinyl pyrolidone and acetic ether copolymer, 5 percent to 10 percent; the Polyethylene Glycol 6000, 4 percent to 8 percent; the chalk, 15 percent to 22percent; the titanium pigment, 15 percent to 25 percent; the coloring agent, 2 percent to 10 percent; others, 2 percent to 8 percent; the assistant agent, 2 percent to 6 percent. The present invention resolves the special agent problem that deformation of the Chinese medicine can occur in hot and wet condition. A plurality of kinds of membrane polymer materials is selected and a plurality of kinds of additions are added, which changes feature of the physical membrane in the preparation. Therefore the film coating material is applied more widely and the moisture resistance property is enhanced.
Description
technical field [0001] The invention relates to a film coating premix, in particular to an all-water type film coating premix for traditional Chinese medicine tablets. Background technique [0002] Film coating technology is a pharmaceutical excipient that uses special coating equipment to spray special polymer materials on tablets, capsules or drug granules to achieve the effects of moisture-proof, odor-removing and easy-to-identify carriers. Since 1954, the Abbott Company of the United States produced the first batch of commercially available film-coated tablets, the film-coating technology has changed the situation that sugar-coated tablets have dominated the world for a long time. Its appearance has fundamentally solved the problem of difficult, complicated and uncontrollable quality of the sugar-coating process, enabling the production of tablets to achieve mechanical automation, high efficiency and stable quality, and at the same time providing conditions for sustained...
Claims
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Application Information
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