Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof
A film coating agent and tablet technology, which is applied in the field of pharmaceutical excipients, can solve problems such as the unsatisfactory moisture-proof effect of traditional Chinese medicine tablets and the inability to completely solve the problem of moisture absorption of traditional Chinese medicine, so as to solve the problem of moisture absorption, enhance moisture-proof performance, and expand the scope of use Effect
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[0016] A method for preparing a moisture-proof film coating agent for traditional Chinese medicine tablets consists of the following steps:
[0017] ⑴ Put the vinylpyrrolidone-vinyl acetate copolymer, 5-15 centipoise hypromellose, polyethylene glycol 6000, iron oxide, titanium dioxide and talc into a high-speed mixer at a rotation speed of 2700 rpm. The mixing time is 0.5 to 3 minutes; the speed of the high-speed mixer is 2700 rpm, and the mixing time is 0.5 to 3 minutes.
[0018] ⑵After pouring Tween 80 evenly on the materials in the high-speed mixer, mix at 2700 rpm for 0.5 to 3 minutes to make the finished product of Chinese medicine tablet moisture-proof film coating agent.
Example Embodiment
[0019] Example 1
[0020] A preparation method of a moisture-proof film coating agent for traditional Chinese medicine tablets, comprising:
[0021] (1) Weigh 20 parts of vinylpyrrolidone-vinyl acetate copolymer, 30 parts of 5-15 centipoise hypromellose, 600020 parts of polyethylene glycol, 803 parts of Tween, and iron oxide according to the mass parts ratio. 10 parts, 17 parts talcum powder;
[0022] (2) Pour the vinyl pyrrolidone-vinyl acetate copolymer, 5-15 centipoise hypromellose, polyethylene glycol 6000, iron oxide, titanium dioxide and talc into a high-speed mixer at a rotation speed of 2700 R / min mixing for 2 minutes;
[0023] (3) Pour Tween 80 evenly on the materials in the high-speed mixer, and mix at 2700 rpm for 15 minutes to form a moisture-proof film coating agent for traditional Chinese medicine tablets.
Example Embodiment
[0024] Example 2
[0025] (1) Weigh 50 parts of vinylpyrrolidone-vinyl acetate copolymer, 10 parts of hypromellose 5-15 centipoise, 600010 parts of polyethylene glycol, 803 parts of Tween, and 10 parts of iron oxide according to the mass parts ratio. Parts and 17 parts of talcum powder;
[0026] (2) Put 5-15 centipoise of hypromellose, polyethylene glycol 6000, iron oxide, titanium dioxide and talc into a high-speed mixer, and mix at 2700 rpm for 2 minutes;
[0027] (3) Pour Tween 80 evenly on the materials in the high-speed mixer, and mix at a speed of 2700 rpm for 15 minutes to form a traditional Chinese medicine tablet film coating agent.
[0028] Using conventional methods, the moisture-proof film coating agent of a traditional Chinese medicine tablet of Example 1 and Example 2 is made into a solution, and sprayed on the surface of the traditional Chinese medicine core to form a moisture-proof film coating tablet. Then the moisture resistance test is carried out: the moisture abs...
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