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TGF-beta induced adjustment T cell and its forming method and application

A cell and cytokine technology, applied in the field of biomedicine, can solve the problems of limited T cell therapy for SLE patients

Inactive Publication Date: 2008-02-20
郑颂国 +4
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen that this finding is still limited for regulatory T cell therapy in SLE patients

Method used

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  • TGF-beta induced adjustment T cell and its forming method and application
  • TGF-beta induced adjustment T cell and its forming method and application
  • TGF-beta induced adjustment T cell and its forming method and application

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Embodiment Construction

[0039] The invention uses the combination of cytokine TGF-β and IL-2 to induce peripheral blood to produce a group of regulatory T cells similar to natural CD4+ regulatory cells. The present invention establishes a brand-new method for inducing CD4+regulatory T cells, which replaces the method for expanding natural CD4+CD25+regulatory T cells, and is used for the treatment of SLE or other autoimmune diseases. The present invention finds that two cytokines, TGF-β and IL-2, can induce normal animal and human CD4+ cells to develop into CD4+Foxp3+ regulatory T cells, and these two cytokines also have the ability to induce lupus animals and SLE patients CD4+ cells develop into CD4+Foxp3+ regulatory T cells. Therefore, the present invention plans to obtain peripheral blood CD4+ cells from patients with autoimmune diseases such as SLE, and then isolate CD25+ cell populations after in vitro induction and culture with TGF-β and IL-2 to obtain CD4+CD25+Foxp3+ regulatory T cells. Finall...

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Abstract

The invention pertains to biomedical technique field, in particular to a TGF-beta induced regulatory T-cell and a synthesis method and the applications thereof. The regulatory T-cell of the invention is formed by combining two cytokines: TGF-Beta and IL-2, and obtained by extrinsically inducing CD4+ cells of autoimmune diseases sufferer, and is recorded as CD4++CD25+Foxp3+ regulatory T-cell, wherein FoxP3 is FoxP3 gene or protein. The regulatory T-cell of the invention can be taken as a medicine preparation that is used for treating the diseases of autoimmune diseases (such as SLE) sufferer.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a regulatory T cell related to the treatment of autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, etc.), as well as a formation method and application of the regulatory T cell. Background technique [0002] At present, the treatment of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis at home and abroad relies on hormone or non-hormonal immunosuppressants. Although the treatment of these drugs can control the symptoms of some patients, the long-term efficacy is limited. More importantly, long-term use of these drugs often produces serious complications, or secondary serious infections, and even induces the occurrence of tumors. In addition, the huge cost of medical resources is also a drawback. [0003] In the middle and late 1990s, immunologists discovered that there are a small amount of CD4+CD25+ c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/06C12N5/08A61K35/12A61P37/00A61K35/17C12N5/0783
Inventor 郑颂国邹和建徐建光王菊华戴维·赫威兹
Owner 郑颂国
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