Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue

A nuclear magnetic resonance and tissue technology, applied in the field of identification and characterization of medical conditions, can solve problems that are difficult to treat locally

Active Publication Date: 2008-03-26
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, pain in other joints, such as the spine and other skeletal joints (eg, knuckles, ankles, knees, hips, shoulders, wrists, elbows) may also be caused by multiple different underlying cause, and it is difficult to precisely locate them for direct topical treatment

Method used

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  • Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue
  • Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue
  • Systems and methods using nuclear magnetic resonance (NMR) spectroscopy to evaluate pain and degenerative properties of tissue

Examples

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Embodiment 1

[0076] 1. review

[0077] The aim of this study was to determine the ability of high-resolution magic-angle spinning (HR-MAS) NMR spectroscopy to distinguish different stages of intervertebral disc degeneration. 17 intervertebral discs obtained from human cadavers, using 1D and 2D (TOCSY) 1 HHR-MAS spectrum was analyzed and T was measured 1 and T 2 Relaxation time to determine chemical composition and changes in disc chemical environment with increasing degeneration grade (Thompson grade). Significant findings of the study include: the patterns of the annulus fibrosus and nucleus pulposus samples of the intervertebral discs are very similar; as the Thompson grade increases, the patterns of the annulus fibrosus and nucleus pulposus samples of the intervertebral discs undergo visually significant changes. The area ratios of the N-acetyl to choline regions and the acetyl to carbohydrate regions of the map allowed discs with increased Thompson grade to be distinguished, and th...

Embodiment 2

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Abstract

NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and pain are made. Accordingly, NMR spectroscopy is used to determine location and / or extent of at least one of disc degeneration, or discogenic pain.

Description

[0001] Cross References to Applications [0001] This application claims priority to U.S. Provisional Application Serial No. 60 / 648,241, filed January 28, 2005, which is hereby incorporated by reference in its entirety, and claims U.S. Provisional Application Serial No. 60, filed November 15, 2005 / 731,110 priority, which is also incorporated herein by reference in its entirety. Statement Regarding Federally Sponsored Research or Development [0002] This invention was made with government support under National Institutes of Health Grant Nos. R01-AG17762 and R21-AR51048. The government has certain rights in this invention. References included in submissions on CD-ROM [0003] Not applicable Notice of Copyrighted Material [0004] Portions of the material in this patent document are protected by copyright under the copyright laws of the United States and other countries. The copyright owner has no objection to the facsimile reproduction by anyone of this patent document...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/05
Inventor 沙米拉·马宗达约翰·库尔哈内维奇杰弗里·C·洛茨戴维·S·布拉德福德凯万·克沙里
Owner RGT UNIV OF CALIFORNIA
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