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Method for obtaining nuclear magnetic resonance two-dimension spin echo related spectrum under uneven magnetic field

A spin echo and uniform magnetic field technology, applied in the field of nuclear magnetic resonance spectroscopy detection, can solve problems such as the application of the two-dimensional SECSY method, achieve a simple and effective method, and overcome the effect of non-uniform magnetic field

Active Publication Date: 2014-04-23
XIAMEN UNIV
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Problems solved by technology

[0004] It can be seen that the unideal magnetic field conditions limit the application of two-dimensional SECSY spectrum. Although there have been a series of hardware or software shimming methods to improve the uniformity of the magnetic field, due to its own limitations, there is no way to make the two-dimensional SECSY method applicable. to an unfavorable magnetic field environment

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  • Method for obtaining nuclear magnetic resonance two-dimension spin echo related spectrum under uneven magnetic field
  • Method for obtaining nuclear magnetic resonance two-dimension spin echo related spectrum under uneven magnetic field
  • Method for obtaining nuclear magnetic resonance two-dimension spin echo related spectrum under uneven magnetic field

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[0037] This new method scans a conventional chemical sample solution as an example, and uses this specific example to verify the feasibility of the present invention. The samples used in the experiment were butyl methacrylate (CH 2 C(CH 3 ) COOCH 2 CH 2 CH 2 CH 3 , solute) in DMSO ((CH 3 ) 2 SO, solvent) solution, the experimental test was carried out under a Varian 500MHz NMR spectrometer (Varian, Palo Alto, CA), and no artificial shimming operation was performed during the whole experimental process. According to the operation flow of the high-resolution two-dimensional spin-echo correlation spectrum method above, firstly a one-dimensional spectrum is obtained by sampling with a conventional simple one-dimensional pulse sequence, and the sampling time is 2s. The result is as follows figure 2 As shown, the spectral line width of 120 Hz can be obtained from this one-dimensional spectrum. Since the sample is directly sampled without shimming, the uniformity of the magne...

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Abstract

A method for obtaining a nuclear magnetic resonance two-dimension spin echo related spectrum under an uneven magnetic field relates to a nuclear magnetic resonance wave spectrum detection method and comprises the steps of using a normal one-dimension pulse sequence to sample a one-dimension spectrum, obtaining the line width of spectral lines, and providing a basis for spectrum width parameter setting, wherein the line width value also reflects the uniformity condition of a magnetic field; introducing well precompiled two-dimension spin echo related spectrum pulse sequences onto a nuclear magnetic resonance spectrometer; opening a multi-quantum coherent signal selection module, a three-dimension sampled indirect dimension evolution period t1 combination and indirect dimension evolution period t2 combination and an echo delay module among the two-dimension spin echo related spectrum pulse sequences; setting each experiment parameter of the two-dimension spin echo related spectrum pulse sequences; executing the two-dimension spin echo related spectrum pulse sequences, of which the experiment parameters are set, for data sampling; after the data sampling is finished, performing related data postprocessing to obtain the two-dimension spin echo related spectrum uninfluenced by the uneven magnetic field. The method has no need of shimming operation and is simple, convenient and effective.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance spectroscopy detection method, in particular to a method for obtaining a high-resolution nuclear magnetic resonance two-dimensional spin echo correlation spectrum under an inhomogeneous magnetic field. Background technique [0002] Two-dimensional spin echo correlation spectroscopy (Spin-Echo Correlated SpectroscopY, SECSY) is one of the earliest proposed two-dimensional spectroscopy methods in the field of NMR. The conventional SECSY sequence is composed of a π / 2 pulse, a π pulse, and an indirect dimensional evolution period t divided in half 1 and a sampling period t 2 constitute. This conventional SECSY method was proposed by Ernst in 1979 (Aue W.P., Bartholdi E., and Ernst R.R. Two-dimensional spectroscopy application to nuclear magnetic resonance[J].J.Chem.Phys.,1976,64,2229 -2246), usually a two-dimensional SECSY spectrum contains principal component peaks and cross peaks, where the princip...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/565
Inventor 黄玉清陈忠
Owner XIAMEN UNIV
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