'Zishuiqinggan'oral preparation and preparation thereof

An oral preparation and liver-clearing technology, applied in the field of medicine, can solve problems such as inaccurate dosage, large dosage of traditional Chinese medicine decoction, and inability to commercialize

Inactive Publication Date: 2008-08-13
张文芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] The ancient "Zi Shui Qing Gan" only has a decoction, which needs to be decocted and taken after purchasing the decoction pieces. It is very inconvenient to carry and take it. After research, we have made a modern oral preparation of traditional Chinese medicine through quantitative control of the index components. The product dosage is accurate and the quality is stable. , easy to take, suitable for large-scale commercial production, overcomes the shortcomings of traditional Chinese medicine decoctions such as large dosage, inaccurate dosage, inconvenient carrying and taking, and inability to commercialize, and is convenient for clinical treatment and home use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Preparation method of "Zi Shui Qing Gan" extract 1 (extract and volatile oil)

[0050] Prescription: Rehmannia glutinosa 15g, angelica 9g, white peony 10g, jujube kernel 10g, cornus 10g, poria cocos 9g, yam 12g, Bupleurum 9g, mountain gardenia 9g, paeonol 9g, Alisma 9g.

[0051] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 6-15 times the amount of water to soak for 2-10 hours, heat and boil for 2-3 times, combine the extracts, collect volatile oil; water extraction The liquid was left to stand for 12-48 hours, filtered to get the supernatant, concentrated under reduced pressure to obtain a medicinal extract of about 22.2 g of water extract and about 0.03 g of volatile oil.

Embodiment 2

[0052] Example 2: Preparation method of "Zi Shui Qing Gan" extract 2 (dry powder and volatile oil)

[0053] Prescription: Rehmannia glutinosa 15g, angelica 9g, white peony 12g, jujube kernel 9g, cornus 9g, poria cocos 9g, yam 12g, bupleurum 9g, mountain gardenia 9g, paeonol 9g, alisma 9g.

[0054] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 8-10 times the amount of water to soak for 2-8 hours, heat to boiling and extract 2-3 times, combine the extracts, collect volatile oil; water extraction The liquid was left to stand for 12-48 hours, filtered to take the supernatant, concentrated under reduced pressure, and spray-dried to obtain a dry powder of about 24.2g of water extract; about 0.03g of volatile oil.

Embodiment 3

[0055] Embodiment 3: Preparation method of oral solid preparation of "Zi Shui Qing Gan"

[0056] (1) Preparation of "Zi Shui Qing Gan" Granules

[0057] prescription:

[0058] "Zi Shui Qing Gan" Extract 1 10-90%

[0059] Starch 5.0-70%

[0060] Dextrin 2.0-20%

[0061] Xylitol 5.0-20%

[0062] Methyl sorbate 0.001-2.0%

[0063] Preferred Prescription:

[0064] "Zi Shui Qing Gan" Extract 1 22.2g

[0065] Starch 10.0g

[0066] Dextrin 3.0g

[0067] Xylitol 2.0g

[0068] Methyl sorbate 0.002g

[0069] Preparation method: Prepare the extract of "Zi Shui Qing Gan" according to the method in Example 1, add the prescribed amount of auxiliary materials to make granules according to the conventional method, dissolve the volatile oil with an appropriate amount of ethanol, spray evenly on the granules, dry at low temperature, pack and make Into three bags, each bag 10.1g.

[0070] (2) Preparation of "Zi Shui Qing Gan" tablet:

[0071] (1) Ordinary tablet prescription:

[...

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PUM

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Abstract

The present invention relates to a zishuiqinggan oral liquid preparation which is prepared from 11 Chinese traditional medicines including rehmanniae vaporata etc., and a method for preparing the same. The preparation is prepared from mixed extract (including extractum or dry powder and volatile oil) including rehmanniae vaporata, angelica, zaoren, cornus officinalis, tuckahoe, yarm, bupleurum, capejasmine, cortex moutan, americanwater plantain as raw materials, and acceptable carrier or excipient as substrate in medicine by conventional process. The preparation has good property of nourishing yin and blood, dispersing stagnant liver and clearing away heat for treating yin deficiency and liver depression, hypochondrial distending pain, gastric cavity pain, dry throat with a bitter taste, red tongue and less tongue coating, pulse deficiency and wiry or thin soft. The medicine preparation is used for treating chronic hepatitis, neurasthenia, climacteric syndrome, neurosis, masculine sterility and hypertension in clinical.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an oral preparation for mainly treating yin deficiency and liver stagnation, hypochondrium distending pain, epigastric pain and a preparation method thereof, in particular to an extract of a traditional Chinese medicine prescription of nourishing water and clearing liver as the active ingredient of the medicine oral preparations. Background technique [0002] "Zi Shui Qing Gan Drink" comes from "Yi Zong Ji Ren Bian", which is composed of Bupleurum, Angelica, Paeoniae Alba, Gardenia, Cornus officinalis, Poria cocos, Chinese yam, Moutan bark, Alisma, Rehmannia glutinosa, etc. From the perspective of the composition, Composed of Liuwei Dihuang Pills and Danzhi Xiaoyao Powder, it has the effects of nourishing yin and nourishing blood, soothing the liver and clearing away heat. It is used to treat yin deficiency and liver depression, hypochondrium pain, epigastric pain, dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61K47/20A61K47/36A61K47/40A61K47/44A61P1/04A61P1/16A61P9/12A61P15/08A61P15/12A61P25/20
Inventor 张文芳曹世栋
Owner 张文芳
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