Dioscorea opposita saponin liposome, method for preparing its preparations and uses thereof

A technology of dioscin and dioscin, applied in the application of dioscin liposome preparations in the prevention and treatment of cardiovascular disease drugs, the field of preparation of dioscin liposomes and preparations thereof, can solve the problems of phospholipids prone to hydrolysis and oxidation reactions, Affect dioscin lipid stability, thermodynamic instability and other issues, to achieve the effect of facilitating transportation and storage, good adhesion, and prolonging the action time
CN101244040BActive Publication Date: 2010-08-11江苏黄河药业股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
江苏黄河药业股份有限公司
Publication Date
2010-08-11

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Abstract

The invention relates to a yam saponin liposome, a preparation method of the yam saponin liposome and the application of yam saponin liposome in preparing the medicine for prevention and treatment of cardiovascular diseases. The composition (parts by weight) of the yam saponin liposome is as follows: phospholipid 1 to 1000, cholesterol 0.5 to 100, yam saponin 1 to 200 and emulsifier 20 to 500. The yam saponin liposome has the advantages of high optical and thermal stability, ability to prolong the active time of the medicine, simple and economical process and convenient transportation and storage compared with the prior art since the yam saponin liposome can be made into coated tablet, syrup, oral liquid, drops and capsules, and obvious therapeutic effect proven by the clinical trial for the cardiovascular diseases such as coronary heart disease and hyperlipidemia.
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Description

technical field The invention relates to the preparation and use of a traditional Chinese medicine liposome and its preparation, in particular to the preparation method of the diosgenin liposome and the preparation thereof, and the application of the dioscin liposome preparation in drugs for preventing and treating cardiovascular diseases. Background technique Dioscorea saponin is the extract of the rhizome of Dioscorea Nipponica Makino (Dioscorea Nipponica Makino), which has a clear chemical structure and high oral absorption and utilization. Obvious protective effect, relieve angina pectoris; regulate fat, reduce blood viscosity, inhibit platelet aggregation, improve microcirculation, prevent thrombosis; reduce artery wall lipid infiltration and plaque formation, prevent atherosclerosis; reduce heart load, reduce Myocardial oxygen consumption, improve heart function. But at present, the diosgenin raw material drug is unstable to light and heat, and is not easy to store. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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