Dioscorea opposita saponin liposome, method for preparing its preparations and uses thereof

Abstract

The invention relates to a yam saponin liposome, a preparation method of the yam saponin liposome and the application of yam saponin liposome in preparing the medicine for prevention and treatment of cardiovascular diseases. The composition (parts by weight) of the yam saponin liposome is as follows: phospholipid 1 to 1000, cholesterol 0.5 to 100, yam saponin 1 to 200 and emulsifier 20 to 500. The yam saponin liposome has the advantages of high optical and thermal stability, ability to prolong the active time of the medicine, simple and economical process and convenient transportation and storage compared with the prior art since the yam saponin liposome can be made into coated tablet, syrup, oral liquid, drops and capsules, and obvious therapeutic effect proven by the clinical trial for the cardiovascular diseases such as coronary heart disease and hyperlipidemia.

Description

technical field The invention relates to the preparation and use of a traditional Chinese medicine liposome and its preparation, in particular to the preparation method of the diosgenin liposome and the preparation thereof, and the application of the dioscin liposome preparation in drugs for preventing and treating cardiovascular diseases. Background technique Dioscorea saponin is the extract of the rhizome of Dioscorea Nipponica Makino (Dioscorea Nipponica Makino), which has a clear chemical structure and high oral absorption and utilization. Obvious protective effect, relieve angina pectoris; regulate fat, reduce blood viscosity, inhibit platelet aggregation, improve microcirculation, prevent thrombosis; reduce artery wall lipid infiltration and plaque formation, prevent atherosclerosis; reduce heart load, reduce Myocardial oxygen consumption, improve heart function. But at present, the diosgenin raw material drug is unstable to light and heat, and is not easy to store. ...

AI Technical Summary

Problems solved by technology

However, since dioscin liposomes belong to a colloidal dispersion system and a thermodynamically unstable system, the phospholipids of its membrane material are prone to hydrolysis and oxidation reactions, and the temperature and pH value of the external environment cause changes in the liposome structure, thereby causing lipid Leakage of drugs in the body, affecting the stability of diosgenin lipids during storage

This is a technical problem that has not been well solved for a long time

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