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Pharmaceutical combination and medicament use thereof

A technology of composition and medicine, applied in the field of pharmaceutical composition and its medical application, can solve the problems of unsatisfactory clinical curative effect of neuroprotective agents, lack of basic and clinical research, etc., achieve obvious neuroprotective effect, improve quality of life, promote The effect of neurological recovery

Inactive Publication Date: 2008-08-27
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, in actual clinical practice, nerve damage often involves a variety of pathological processes. The clinical efficacy of any of the above-mentioned neuroprotective agents is not ideal, and there is a lack of relevant basic and clinical research for combined use. Therefore, research on neuroprotective agents Like clinical use, breakthroughs in ideas or methods of use are urgently needed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The present embodiment is the pharmaceutical composition (granule) that is made from the Chinese medicine extract of following proportioning by weight:

[0051] 5 parts of ginseng stem and leaf total saponin extract, 5 parts of breviscapine total flavonoids extract, 10 parts of breviscapine total caffeate extract.

[0052] in:

[0053] The total saponin extract of ginseng stems and leaves is a substance extracted from ginseng stems and leaves by the following method:

[0054] Take ginseng stems and leaves, add 8 times the amount of water, decoct and extract 3 times, each time for 1 hour, filter, combine the filtrates, concentrate to a thick paste, and dry to obtain the total saponin extract of ginseng stems and leaves, the total saponin content of which is 25 %.

[0055] Erigeron scutellaria total flavonoids extract and scutellaria scutellaria total caffeate extract are substances extracted from scutellaria scutellaria by the following method:

[0056] Take the medic...

Embodiment 2

[0061] The present embodiment is the pharmaceutical composition (capsule) that is made from the crude drug of following weight portion proportioning:

[0062] 8 parts of total saponin extract from stems and leaves of ginseng, 12 parts of total flavonoids extract from breviscapine, 7 parts of total caffeate extract from breviscapine.

[0063] in:

[0064] The total saponin extract of ginseng stems and leaves is a substance extracted from ginseng stems and leaves by the following method:

[0065] Take ginseng stems and leaves, add 8 times the amount of water, decoct and extract 3 times, each time for 1 hour, filter, combine the filtrate, concentrate until the medicine is 1 / 2 of the weight of the medicine, add ethanol to make the ethanol concentration reach 80%, refrigerate at 4 °C , left to stand for 24 hours, filtered, and the filtrate was recovered with ethanol, concentrated, and dried to obtain the total saponin extract of ginseng stems and leaves, the total saponin content ...

Embodiment 3

[0074] The present embodiment is the pharmaceutical composition (tablet) that is made from the crude drug of following weight portion proportioning:

[0075] 12 parts of ginseng total saponin extract, 17 parts of breviscapine total flavonoids extract, 13 parts of breviscapine total caffeate extract.

[0076] in:

[0077] Ginseng total saponins extract is a substance extracted from ginseng by the following method:

[0078] ①Water extraction: Take ginseng medicinal materials, crush them, add water to extract 3 times, add 10 times the amount of water for 3 hours for the first time, add 8 times the amount of water for 2 hours for the second time, add 6 times the amount of water for 0.5 hours for the third time , combine the water extracts and concentrate to 1 / 2 of the weight of the medicinal materials;

[0079] ② Alcohol precipitation: Add ethanol to the concentrated water extract of the above ① to make the ethanol concentration reach 80%, refrigerate at 4°C, let stand for 24 ho...

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Abstract

The invention discloses a drug combination, which is mainly formed by traditional Chinese medicine extracts according to the proportion by weight as follows: the total saponin extract of ginseng or ginseng cauline leaf is 1 to 20 parts, the total flavone extract of erigeron is 1 to 20 parts, and the total caffeic acid ester of the erigeron is 1 to 20 parts. Adopting the conventional traditional Chinese medicine combination formula, the drug combination has obvious neuroprotective effect and neural function improving, etc, by combining with the characteristics and advantages of the Chinese herb compound that are multi-component, multi-target, multi-level and multiple ways for treating complex disease; the drug combination can effectively block most pathological mechanisms of a plurality of disease nerve injuries such as ischemic cerebrovascular disease; particularly, in the aspect of improving the neurological symptom, the traditional Chinese medicine injection is helpful to enhance the living quality of the patient, achieves the purpose of improving prognosis, and has important clinical application significance. The invention futher discloses the pharmaceutical application of the drug combination.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition and its medical application. Background technique [0002] Nerve injury mainly includes cranial nerve injury, spinal cord injury and peripheral nerve injury. [0003] Cranial nerve injury includes traumatic brain injury, sequelae of cerebrovascular sclerosis (cerebral hemorrhage, cerebral thrombosis), sequelae of encephalitis and meningitis, sequelae of demyelinating diseases and other sequelae of cerebrovascular diseases. [0004] Cerebrovascular disease is a common disease worldwide. In my country, ischemic cerebrovascular disease is the main disease. It has the characteristics of high morbidity, high fatality rate and high disability rate. Once it occurs, it will bring great harm to patients and families mental distress and financial burden. [0005] According to the results of modern medical research, the essence of ischemic c...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P25/00A61P25/02A61P9/10
Inventor 唐德江陈犁李文军
Owner 重庆希尔安药业有限公司
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