Oral preparation containing mydecamycin, preparation method and application thereof

A midecamycin and preparation technology, applied in the field of therapeutic drugs and its preparation, can solve the problems of long time to reach effective blood drug concentration, affect effective antibacterial efficacy, low blood drug concentration, etc., achieve rapid onset of action, and improve antibacterial ability , The effect of simple production process

Inactive Publication Date: 2008-09-24
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the slow oral absorption of tablets and capsules, the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentrati

Method used

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  • Oral preparation containing mydecamycin, preparation method and application thereof
  • Oral preparation containing mydecamycin, preparation method and application thereof
  • Oral preparation containing mydecamycin, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0043] Example 1 - Medimycin Candy

[0044] Prescription: Mideamycin 100g, sucrose 843.5g, citric acid 10g, food coloring-400.1g, mannitol 10g, hypromellose 36.5g, dosage 1000 tablets.

[0045] Method: Prepare a mixture of 100g midecamycin, 10g citric acid, 400.1g food coloring, 10g mannitol and 36.5g hypromellose, grind and pass through a 20-mesh sieve. Take 843.5 grams of sucrose, heat it to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, place it on a product forming machine and extrude it. Each lozenge weighs 2 grams. Then, the disintegration time limit of midiomycin candy in 900ml of water at 37°C and the dissolution rate when completely disintegrated were determined.

[0046] Results: The disintegration time limit was 28-32 minutes, and the dissolution rate at complete disintegration was 83%-87%.

Example Embodiment

[0047] Example 2 - Low sugar midiomycin candy

[0048] Prescription: Mideamycin 100g, sucrose 193.5g, fructooligosaccharide 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-400.1g, mannitol 10g, hypromellose 36.5g, dosage 1000 piece.

[0049] Method: prepare a mixture of citric acid 10g, food coloring-400.1g, mannitol 10g, and hypromellose 36.5g, grind and pass through a 20-mesh sieve. Take 193.5 g of sucrose, 300 g of fructooligosaccharides, 300 g of xylitol, and 50 g of inulin, mix, heat to 140 °C to melt, add the sieved mixture, stir rapidly for 10 minutes, cool to 85 °C, add 100 g of midecamycin, Stir rapidly for 10 minutes, place on a product forming machine and extrude, each lozenge weighs 2 grams. Then, the disintegration time limit of midiomycin candy in 900ml of water at 37°C and the dissolution rate when completely disintegrated were determined.

[0050] Results: The disintegration time limit was 31-36 minutes, and the dissolution rate at complete di...

Example Embodiment

[0051] Example 3-Midimycin Buccal Tablets

[0052] Prescription: Mideamycin 100g, Hypromellose 128g, Polyethylene Glycol 6000 771 grams, aspartame 1 gram.

[0053] Method: prepare 128 grams of hypromellose, polyethylene glycol 6000 771 grams, 1 gram of aspartame mixed matrix, heated and melted, cooled to 80 ° C, added 100 grams of midecamycin, stirred and mixed, cooled at room temperature until solidified, granulated, placed on a tablet machine and extruded to form, each tablet Lozenges weigh 1 gram. Then, the disintegration time limit of midecamycin buccal tablets in 900ml water at 37°C and the dissolution rate when completely disintegrated were determined.

[0054] Results: The disintegration time limit was 24-32 minutes, and the dissolution rate when completely disintegrated was 83%-89%.

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Abstract

The invention relates to a buccal tablet containing medecamycin, the preparation method and the use. The buccal tablet aims to provide a buccal tablet with medecamycin adopted as the medicinal ingredient. The buccal tablet can be dissolved among the salvia in the oral cavity and enter the oral cavity, the pharynx and pharyngeal tonsils to play the role of resisting bacteria. The buccal tablet adopts medecamycin and derivatives of medecamycin as medicinal ingredients and can be made into various pharmaceutical formulations, such as buccal tablets, candies, dropping pills and so on. The buccal tablet containing Azithromycin has the characteristics of fast effect, excellent curative effect and convenient drug delivery, can directly improve the concentration of antibiotic drugs at the pathological part and enhance the antibacterial capacity of the pathological part, and is more suitable for majorities of patients.

Description

technical field [0001] The invention relates to a therapeutic drug and its preparation method and application, in particular to an oral preparation containing midecamycin and its preparation method and application. Background technique [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/00A61K9/20A61K47/38A61K47/40A61K47/42A61P11/04A61P1/02A61J3/06A61K47/10A61K47/14
Inventor 刘凤鸣
Owner 刘凤鸣
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