Substance assistant laser desorpted ionized biological aerosol mass spectrometer

A matrix-assisted laser, bio-aerosol technology, applied in instruments, scientific instruments, material analysis by electromagnetic means, etc., can solve difficult bio-aerosol analysis of bio-macromolecules, complex mass spectra, organic and bio-macromolecular fragments to improve the injection efficiency and signal strength

Inactive Publication Date: 2008-10-22
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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Problems solved by technology

This method of directly using laser to desorb and ionize the aerosol will cause serious fragmentation of organic and biomacromolecules, making the mass spectrum very complicated, and it is difficult to analyze the biomacromolecules of bioaerosols. Therefore, the current aerosol mass spectrometer mainly For the analysis of inorganic and organic small molecule components in aerosols

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  • Substance assistant laser desorpted ionized biological aerosol mass spectrometer
  • Substance assistant laser desorpted ionized biological aerosol mass spectrometer

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specific Embodiment approach

[0012] The main part of the matrix-assisted laser desorption ionization bioaerosol mass spectrometer consists of a mixing chamber (1), a sample injection chamber (2), a beam source chamber (3), a differential chamber (4), an ionization chamber (5) and a reflective mass spectrometer (6) consists of six parts. The specific implementation method is:

[0013] One, the bioaerosol is directly sucked in the mixing chamber (1) from the atmosphere by the bioaerosol inlet (11) with a diameter of 1 mm;

[0014] Two, in the mixing chamber (1), the bioaerosol is fully mixed with the matrix (comprising gaseous matrix and granular matrix);

[0015] 3. The mixture of bioaerosol and matrix enters the sampling chamber (2) through the sampling chamber inlet (12) with a diameter of 1 mm under pressure-controlled conditions;

[0016] 4. The mixture of bioaerosol and matrix enters the pneumatic focusing lens (14). The pneumatic focusing lens (14) is composed of 6 to 8 pneumatic focusing lenses. I...

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Abstract

The invention relates to a substrate auxiliary laser desorption ionization biological aerosol spectrometer capable of performing real-time analysis and detection on biological aerosol in the air. The substrate auxiliary laser desorption ionization biological aerosol spectrometer directly samples the biological aerosol in the natural environment, adopts the technology of premixing and control pressure sampling of the biological aerosol and substrates (comprising gaseous substrates and granular substrates), and focalizes the aerosol and substrate mixture into granular beams into particle beams through a pneumatic focusing lens; the biological aerosol and the substrate mixture are desorbed and ionized by pulse laser beams; ions produced are accelerated by an accelerating electrode, focalized by an ion focusing lens and then detected by a reflection type mass spectrum device, and then a mass spectrum of the biological aerosol is obtained; and biological information in the biological aerosol is obtained through mass spectrum analysis.

Description

Technical field [0001] The invention relates to a matrix-assisted laser desorption ionization biological aerosol mass spectrometer, which is an instrument that can directly continuously monitor and analyze biological aerosol in the atmosphere. Background technique [0002] Bioaerosols generally refer to particulate matter in the atmosphere that contains biomass components (such as bacteria, fungi, viruses, pollen, protozoa, and plant fibers, etc.). Bioaerosols are an important source of infectious and allergic diseases, such as tuberculosis caused by bacteria, influenza caused by viruses, mycoses caused by fungi, and allergic diseases caused by pollen, etc., which endanger human health. Explosive infectious diseases such as SARS and influenza will not only cause direct economic losses, but also have an impact on social stability and security. [0003] The traditional bioaerosol detection method is to use microscope to observe and analyze its morphology after sampling and to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/64
Inventor 束继年李曜高绍凯
Owner RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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