Sustained release preparation containing domperidone pantoprazole sodium and its preparation method

Abstract

The invention relates to a compound preparation containing domperidone and pantoprazole sodium, and a preparation method. In the compound preparation, the domperidone comprises a sustained-release part and an immediate-release part, and the pantoprazole sodium is a common release component. The invention discloses a preparation method of the compound preparation.

Description

technical field The invention relates to a compound domperidone hydrochloride pantoprazole sodium slow-release preparation for reflux esophagitis, functional dyspepsia, gastric ulcer, duodenal ulcer and the like and a preparation method thereof. Background technique The mechanism of peptic ulcer (stomach and duodenal ulcer) has not been fully clarified so far. Most people think that "no acid, no ulcer", and formed a drug regimen mainly to suppress gastric acid. At the same time as acid, we should also pay attention to the eradication of Hp. Whether Hp can be eliminated is the key factor to prevent ulcer recurrence. In my country, according to the drug purchase data of more than 300 sample hospitals in 16 major cities, the total amount of the five major types of drugs used for the treatment of peptic ulcer in 2005 reached 677 million yuan, and 540 million yuan in 2004, an increase of 24.3%. Since 2002, the purchase amount of peptic ulcer treatment drugs has maintained a do...

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