Sustained release preparation containing pseudoephedrine and desloratadine and preparation process thereof

A technique of pseudoephedrine and sustained-release preparations, applied in the sustained-release preparations containing pseudoephedrine and deretadine and the field of preparation thereof, can solve the problems such as the related literature and patent reports of compound pseudoephedrine and deretadine sustained-release preparations that have not been seen

Inactive Publication Date: 2007-07-11
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Through the search, there are no relevant literature and patent reports on the compound pseudoephedrine deratadine sustained-release preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 compound pseudoephedrine sulfate deratadine double-layer sustained-release tablet

[0020] prescription:

[0021]

[0022] Pseudoephedrine Sulfate 120g

[0023] HPMC-15M 30g

[0024] HPCM-100M 70g

[0025] Stearic acid 10g

[0026] Lactose 30g

[0027]

[0028] 70% alcohol solution appropriate amount

[0029]

[0030] Deratadine 5g

[0031] Microcrystalline Cellulose 15g

[0032] Appropriate amount of purified water

[0033] Appropriate amount of talcum powder

[0034] A total of 1000 pieces were made

[0035]

[0036] Preparation:

[0037] Pass pseudoephedrine sulfate through a 100-mesh sieve, grind stearic acid, pass HPMC-15M, HPCM-100M, and lactose through a 60-mesh sieve, mix the raw and auxiliary materials evenly, use 70% ethanol solution to make soft materials, gra...

Embodiment 2

[0038] Embodiment 2 compound pseudoephedrine sulfate deratadine film-coated sustained-release tablet

[0039] prescription:

[0040]

[0041] Pseudoephedrine Sulfate 60g

[0042]

[0043] Microcrystalline Cellulose 250g

[0044] Lactose 75g

[0045] Deratadine 5g

[0046] Ethyl cellulose aqueous dispersion 20g

[0047] HPMC 8g

[0048] PEG4000 3g

[0049] Talc powder 4g

[0050] Absolute ethanol 80ml

[0051] Appropriate amount of purified water

[0052] A total of 1000 pieces were made

[0053]

[0054] Preparation:

[0055] Pass pseudoephedrine sulfate through a 100-mesh sieve, microcrystalline cellulose and lactose through a 60-mesh sieve, mix the raw and auxiliary materials evenly, make soft materials with an appropriate amount of water, granulate with a 20-mesh sieve, dry, granulate with a 18-mesh sieve, a...

Embodiment 3

[0056] Example 3 Compound Pseudoephedrine Deratadine Sustained Release Tablets

[0057] prescription:

[0058]

[0059] Pseudoephedrine Sulfate 180g

[0060]

[0061] Deratadine 5g

[0062] HPMC-15M 50

[0063] HPMC-100M 75g

[0064] Calcium dihydrogen phosphate 25g

[0065] 80% ethanol appropriate amount

[0066] Acrylic resin E (stomach solution) 4g

[0067] Talc powder 3g

[0068] 80% ethanol 150ml

[0069] A total of 1000 pieces were made

[0070]

[0071] Preparation:

[0072] Pass pseudoephedrine sulfate through a 100-mesh sieve, HPMC-15M, HPMC-100M, and calcium dihydrogen phosphate pass through a 60-mesh sieve, use 80% ethanol solution to make soft materials, granulate with a 16-mesh sieve, dry, granulate with a 16-mesh sieve, and tablet ; take another landratadine and add it to the prepared acrylic resin E55 solution, and set ...

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PUM

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Abstract

The invention relates to a slow-release drug with pseudoephedrine and dileitadin, and relative production, wherein it is formed by slow-releaser and quick-releaser; the pseudoephedrine is slow releaser which will release 30-60% in second hour, release 50-80% in fourth hour, and 80% in eighth hour; the dileitadin is quick releaser which will release 75% in 30min. The invention will release quickly after orally intake. The invention also provides relative external releaser character and preparation.

Description

technical field [0001] The invention relates to a compound pseudoephedrine deratadine slow-release preparation for alleviating symptoms of allergic rhinitis associated with cough with abnormal secretions, such as sneezing, runny nose, nasal itching, and tearing, and a preparation method thereof. Background technique [0002] Flu, commonly known as "cold", is a common respiratory disease caused by multiple viruses, 30%-50% of which is caused by a certain serotype of rhinovirus. Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonals is not just the same yet. The distribution of cold cases is sporadic, does not cause epidemics, and is often easily combined with bacterial infections. The onset of the common cold is rapid. Early symptoms include dry itching or burning sensation in the throat, sneezing, nasal congestion, and runny nose. It starts as clear watery nasal discharge, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K47/38A61K47/36A61K47/32A61K47/14A61K47/12A61K47/10A61K9/22A61P11/02A61P11/14A61P37/08A61K31/137
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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