Novel composing prescription sustained-release preparation for treating high blood pressure and preparation method thereof

Abstract

The invention relates to a sustained release preparation of a novel prescription for treating hypertension and the preparing method thereof. The novel prescription comprises a heart selective Beta1 receptor blocker metoprolol and an angiotensin II receptor antagonist (sartan drugs). The sustained release preparation consists of delayed release part and rapid release part, wherein the heart selective Beta1 receptor blocker metoprolol is the delayed release part, with first hour releasing 25-45%, fourth hour releasing 40-75% and eighth hour releasing over 75%; the angiotensin II receptor antagonist (sartan drugs) is the rapid release part, with 45 minutes dissolution over 75%. The composition has both rapid and prolonged action. The invention discloses in vitro drug release characteristics and preparation method thereof.

Description

technical field [0001] The invention relates to a sustained-release preparation of a new prescription for treating hypertension and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Metoprolol is a selective β1 receptor blocker, which can block myocardial β1 receptors, slow down heart rate, inhibit cardiac contractility and atrioventricular conduction, reduce cardiac output and circulating blood flow, and reduce myocardial oxygen consumption ; It can also reduce the secretion of renin and aldosterone, reduce vascular tension, blood volume and blood pressure. It can be used to treat hypertension and angina pectoris, reduce the incidence of myocardial infarction, and reduce the mortality rate after myocardial infarction. One study confirmed the efficacy of metoprolol extended-release tablets in the treatment of hypertension. Methods: Thirty-eight hypertensive patients of Han and Han ethnic groups took metoprolol sustain...

AI Technical Summary

Problems solved by technology

[0004] Both metoprolol and angiotensin II receptor antagonists can be used to treat hypertension. They have different action sites and methods to indirectly or directly play a role in lowering blood pressure. Clinically, doctors can choose according to their needs. Appropriate angiotensin II receptor antagonists and metoprolol are used in combination to achieve a synergistic effect, but often due to inaccurate dose control, it will bring discomfort to patients or fail to achieve the ideal antihypertensive effect