Novel boronate complex and its use in a glucose sensor

A sensor and glucose technology, applied in the direction of instruments, biological testing, scientific instruments, etc., can solve the problems of unsuitable mass production and time-consuming manufacturing
CN101360987AInactive Publication Date: 2009-02-04SMART HOLOGRAMS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SMART HOLOGRAMS
Publication Date
2009-02-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose- binding boronate and a cationic species held within the sensor.
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Description

technical field

[0001] The present invention relates to new borate ester complexes and their application in glucose sensors. Background technique

[0002] A reliable personal glucose monitor is very important for people with diabetes. Currently, blood glucose measurement is accomplished using hand-held devices, which requires invasive needle stick sampling of blood glucose levels. These tests are painful and inconvenient, need to be performed multiple times a day, do not provide a continuous measurement, and run the risk of missing important fluctuations in glucose levels.

[0003] Subcutaneously implantable sensors that are permanently in contact with interstitial fluid, or contact-lens sensors that measure glucose levels in tear fluid, could be used for non-invasive blood glucose monitoring. Enzyme-based systems utilizing glucose oxidase currently used for invasive blood glucose monitoring are unlikely to be suitable for this purpose. Their high cost, lack of stability,...

Claims

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