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Novel boronate complex and its use in a glucose sensor

A sensor and glucose technology, applied in the direction of instruments, biological testing, scientific instruments, etc., can solve the problems of unsuitable mass production and time-consuming manufacturing

Inactive Publication Date: 2009-02-04
SMART HOLOGRAMS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these materials are time-consuming to manufacture and may not be suitable for mass production

Method used

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  • Novel boronate complex and its use in a glucose sensor
  • Novel boronate complex and its use in a glucose sensor
  • Novel boronate complex and its use in a glucose sensor

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Embodiment Construction

[0033] The invention is suitable for various types of sensors and can be used for qualitative or quantitative detection of glucose. The sensor may be in any suitable form, such as a contact lens or other optical implant. Thus, the invention may be embodied, for example, as a sensor based on a quartz crystal microbalance, a sensor based on surface plasmon resonance, a sensor based on total internal reflection, or preferably (described below by way of illustration) a A holographic sensor.

[0034] The hologram itself can be made from materials known to those skilled in the art. Similarly, boric acid is known. Reference is made to various documents mentioned herein, including WO publications.

[0035] Cationic species that can be used should be capable of being immobilized in polymers or other media. Phosphonium ions and preferably quaternary amines are suitable for this purpose.

[0036] There are various embodiments of the present invention. One is contact lenses (see WO2...

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Abstract

A sensor comprises respective acceptor and donor compounds immobilised in or on a matrix including a glucose-binding boronate and a cationic species, whereby the spacing between the acceptor and donor compounds is reduced in the presence of glucose. For example a holographic sensor comprises a glucose- binding boronate and a cationic species held within the sensor.

Description

technical field [0001] The present invention relates to new borate ester complexes and their application in glucose sensors. Background technique [0002] A reliable personal glucose monitor is very important for people with diabetes. Currently, blood glucose measurement is accomplished using hand-held devices, which requires invasive needle stick sampling of blood glucose levels. These tests are painful and inconvenient, need to be performed multiple times a day, do not provide a continuous measurement, and run the risk of missing important fluctuations in glucose levels. [0003] Subcutaneously implantable sensors that are permanently in contact with interstitial fluid, or contact-lens sensors that measure glucose levels in tear fluid, could be used for non-invasive blood glucose monitoring. Enzyme-based systems utilizing glucose oxidase currently used for invasive blood glucose monitoring are unlikely to be suitable for this purpose. Their high cost, lack of stability,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/77G01N21/47G01N33/66G02B5/32
CPCG02B5/32G01N21/453G01N33/66G01N21/4788
Inventor S·卡比兰M-C·李A·M·霍根K·E·S·梅德洛克
Owner SMART HOLOGRAMS
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