Compound Tranister orally disintegrating tablet preparation and preparation method thereof

The technology of oral disintegrating tablet and preparation is applied in the field of compound tranister oral disintegrating tablet and its preparation, and achieves the effects of fast onset, low side effects and less intestinal residues

Inactive Publication Date: 2011-12-28
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages: the effect is not long-lasting, and it only plays a role in relieving the patient's asthma symptoms; long-term application can lead to down-regulation of β-receptors, making patients desensitized to β-receptor agonists, and even resistant to asthma treatment. Phenomenon
[0007] Ordinary tablets and capsules need to drink water and swallow to complete the medication process. This dosage form has poor compliance for some elderly, children, and patients with difficulty swallowing. In some Restricted use under special conditions (e.g. lack of drinking water)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0032] Tranister 80g

[0033] Salbutamol sulfate 2.4g

[0034] Low-substituted hydroxypropyl cellulose 10g

[0035] Microcrystalline cellulose 20g

[0036] Lactose 60g

[0037] Magnesium stearate 0.3g

[0038] Micro powder silica gel 3.2g

[0039] Sodium carbonate 20g

[0040] Stevia 10g

[0041] The preparation uses a direct tableting process, and the specific preparation process is as follows: the stevia and the main drug are crushed through an 80-mesh sieve, and the stevia and the main drug are mixed uniformly; microcrystalline cellulose, lactose, sodium carbonate, low-substituted hypromellose The base cellulose was passed through an 80-mesh sieve, respectively weighed according to the prescription amount, and then added to the main medicine mixed with stevioside and mixed, and then added the prescription amount of magnesium stearate and micro-powdered silica gel. Content detection. After determining the weight of the tablet, press the tablet to obtain an orally disintegrating tablet....

example 2

[0043] Tranister 80g

[0044] Salbutamol sulfate 2.4g

[0045] Sodium Carboxymethyl Starch 10g

[0046] Microcrystalline cellulose 10g

[0047] Mannitol 60g

[0048] Micronized silica gel 0.3g

[0049] Talc 3.2g

[0050] Citric acid 25g

[0051] Aspartame 10g

[0052] The preparation uses a wet granulation and tableting process, the main drug and each auxiliary material are passed through an 80 mesh sieve, and the prescription amount of the main drug, aspartame, citric acid, sodium carboxymethyl starch, microcrystalline cellulose, and mannitol are respectively weighed. Mix, add proper amount of ethanol as a wetting agent, fully mix the main medicine and auxiliary materials in a wet state. The above-mentioned wet materials are fully dried in a blast drying box, and then sieved after drying. The obtained granules are fully mixed with lubricant and glidant to obtain intermediates. After determining the intermediate content, calculate the tablet weight according to the intermediate content a...

example 3

[0054] Tranister 80g

[0055] Salbutamol sulfate 2.4g

[0056] Croscarmellose Sodium 15g

[0057] Microcrystalline cellulose 25g

[0058] Sucrose 35g

[0059] Magnesium stearate 0.3g

[0060] Talc 3.2g

[0061] Citrate 15g

[0062] Stevia 10g

[0063] The preparation uses a wet granulation and tableting process. The main drug and each auxiliary material are passed through an 80-mesh sieve, and the prescription amount of the main drug, stevia, citric acid, croscarmellose sodium, and microcrystalline cellulose are respectively weighed. Mix lactose, add appropriate amount of ethanol as a wetting agent, fully mix the main medicine and auxiliary materials in a wet state. The above-mentioned wet materials are fully dried in a blast drying box, and then sieved after drying. The obtained granules are fully mixed with lubricant and glidant to obtain intermediates. After determining the intermediate content, calculate the tablet weight according to the intermediate content and then press the table...

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Abstract

The purpose of the present invention is to provide a kind of compound orally disintegrating tablet preparation that is made up of Tranister and salbutamol sulfate and preparation method thereof. In order to achieve the object of the present invention, the specific technical scheme adopted is as follows: compound tranisast orally disintegrating tablet preparation, it is characterized in that, described preparation formula is made up of following components (1000 pieces quantity) by weight: tranisast Special 80.0g, salbutamol sulfate 2.4g, disintegrant 5-30g, filler 10-80g, effervescent agent 5-25g, flavoring agent 0.5-20g, lubricant 0.3-3g. The compound orally disintegrating tablet preparation prepared by the method of the present invention solves the respective defects in the pharmacological effects of the above two drugs in the process of treating bronchial asthma, so that in the process of treatment, it can relieve asthma immediately, and can also maintain and consolidate and it is convenient to take, has quick effect, high bioavailability and good taste. The preparation method of the preparation of the invention has simple steps and low cost.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an orally disintegrating tablet for treating mild and moderate bronchial asthma and chronic asthmatic bronchitis and a preparation method thereof, in particular to a compound trarnister orally disintegrating tablet and a preparation method thereof. Background technique [0002] Tranilast, Li Chuanbei. It is a yellowish white crystalline powder, odorless. The melting point is 267-269°C. Insoluble in water, soluble in alkaline aqueous solution. Made from β-(3,4-dimethoxyphenyl)acrylic acid, it is an anti-allergic drug. It can be used to prevent and treat bronchial asthma, allergic rhinitis, allergic dermatitis, etc. The preparations include tablets and capsules. [0003] Tranister is an allergic mediator blocker, which can inhibit the degranulation of mast cells and the release of allergic mediators caused by allergens and other stimuli, thereby inhibiting the release ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/196A61K9/20A61K47/32A61K47/38A61P11/00A61P11/06A61K31/137
Inventor 张华刘瑶茅仁刚叶晓平张雷
Owner SHANGHAI NORMAL UNIVERSITY
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