Isoquinolinium compound or salts thereof, pharmaceutical composition containing the same, preparation and use thereof

Abstract

The invention discloses isoquinolin compounds shown as a formula I and salts thereof, wherein R1 refers to H, -CH3 or Br. The invention also discloses a preparation method for the compounds, which comprises the step of reacting compounds shown as III under the action of a condensing agent in halogenated alkane or benzene. The invention also discloses a medicine composition containing the compounds, and application of the compounds to preparing medicines for treating arrhythmia. The isoquinolin compounds and the salts thereof have good antiarrhythmic activity and certain function of strengthening myocardial contraction force.

Description

technical field The present invention relates to a class of novel compounds, as well as pharmaceutical compositions containing them, their preparation methods and applications, in particular to a class of isoquinoline compounds or their salts, and their pharmaceutical compositions, their preparation methods and applications. Background technique Sudden cardiac death (SCD) is one of the leading causes of cardiovascular death. The generation of SCD is due to the instability of myocardial electrophysiology, which leads to the disappearance of regular heart rhythm, and the most serious ones are sustained ventricular tachycardia (VT, vetricular tachycardia) and ventricular fibrillation (VF, vetricalar fibrillation). At present, there are many antiarrhythmic drugs, such as sodium channel blockers, β-receptor blockers, calcium channel blockers, and potassium ion channel blockers. In clinical application, it is necessary for antiarrhythmic drugs to slow down the heart rate without...

AI Technical Summary

Problems solved by technology

The problem to be solved by the present invention is to provide a new class of antiarrhythmic drugs that have antiarrhythmic activity and exhibit a certain enhancement effect on myocardial contractility in order to overcome the defect that the existing antiarrhythmic drugs have a strong inhibitory effect on cardiac contractility. The isoquinoline compound or its salt, and its pharmaceutical composition, preparation method and application

Formula I

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