Isoquinolinium compound or its salts, pharmaceutical composition containing the same, preparation and use thereof

Abstract

The invention discloses isoquinolin compounds shown as a formula I and salts thereof. The invention also discloses a preparation method for the compounds, which comprises the step of reacting compounds shown as IV under the action of a reducing agent in an alcohol solvent. The invention also discloses a medicine composition containing the compounds, and application of the compounds to preparing medicines for treating arrhythmia. The isoquinolin compounds and the salts thereof have good antiarrhythmic activity and small function of inhibiting myocardial contraction force.

Description

technical field The present invention relates to a class of novel compounds, as well as pharmaceutical compositions containing them, their preparation methods and applications, in particular to a class of isoquinoline compounds or their salts, and their pharmaceutical compositions, their preparation methods and applications. Background technique Sudden cardiac death (SCD) is one of the leading causes of cardiovascular death. The generation of SCD is due to the instability of myocardial electrophysiology, which leads to the disappearance of regular heart rhythm, and the most serious ones are sustained ventricular tachycardia (VT, vetricular tachycardia) and ventricular fibrillation (VF, vetricalar fibrillation). At present, there are many antiarrhythmic drugs, such as sodium channel blockers, β-receptor blockers, calcium channel blockers, and potassium ion channel blockers. In clinical application, it is necessary for antiarrhythmic drugs to slow down the heart rate without...

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Problems solved by technology

Formula I

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