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Vagina slowly-releasing administration system

A drug delivery system and vaginal technology, applied in the directions of drug combinations, pharmaceutical formulas, and non-active ingredients medical preparations, etc., can solve the problems of drug loss, inability to guarantee curative effect, and curative effect reduction, so as to reduce the probability of side effects and improve drug use. Compliance, to ensure the effect of effective treatment

Inactive Publication Date: 2009-11-11
济南宏瑞创博医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) easy to leak
After the common preparation is administered, it is easy to leak out under the action of vaginal secretions and excretions. On the one hand, the drug is lost and the curative effect cannot be guaranteed. On the other hand, it brings great inconvenience to the patient, thereby reducing the patient's compliance with medication
[0005] 2) frequent use of medication
Due to the problem of leakage, the drug's action time in the vagina is greatly shortened, and the curative effect is reduced. Therefore, in most cases, it is necessary to take the drug once a day, and the frequency of administration is frequent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] prescription composition

[0027] Ornidazole 10%

[0028] Bolosham F127 12%

[0029] Carbomer 934 0.3%

[0030] HPMC K4M 1.5%

[0031] Methylparaben 0.1%

[0032] Propylparaben 0.1%

[0033] water balance

[0034] Preparation:

[0035] Take methylparaben and propylparaben, add water to dissolve and stir evenly, add boloxamer F127, carbomer 934, HPMC K4M while stirring, place at 4°C, after fully dissolved, add Stir the ornidazole passed through a 200-mesh sieve evenly, and pack it into vaginal applicators, 5g each, to obtain.

Embodiment 2

[0037] prescription composition

[0038] Nifuratel 10%

[0039] Nystatin 200,000 units

[0040] Bolosham F127 15%

[0041] Bolosham F68 15%

[0042] HPMC K15M 1%

[0043] Methylparaben 0.1%

[0044] Propylparaben 0.1%

[0045] water balance

[0046] Preparation:

[0047] Take methylparaben and propylparaben, add water to dissolve and stir evenly, add boloxamer F127, boloxamer F68, HPMC K15M while stirring, place at 4°C, after fully dissolved, Add nifuratel and nystatin passed through a 200-mesh sieve, stir evenly, and pack them into vaginal applicators, 5g each, to obtain.

Embodiment 3

[0049] prescription composition

[0050] Clotrimazole 10%

[0051] Bolosham F127 15%

[0052] Bolosham F68 10%

[0053] Carbomer 934 0.05%

[0054] HPMC K4M 3.5%

[0055] Methylparaben 0.1%

[0056] Propylparaben 0.1%

[0057] water balance

[0058] Preparation:

[0059] Take methylparaben and propylparaben, add water to dissolve and stir evenly, add boloxamer F127, boloxamer F68, carbomer 934, HPMC K4M while stirring, and place at 4°C. After being fully dissolved, add clotrimazole passed through a 200-mesh sieve and stir evenly, then pack in vaginal applicators, 5g each, and you get it.

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PUM

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Abstract

The invention relates to a vagina slowly-releasing administration system which comprises a main medicament, a viscosity regulator, a biological adhesive material and other additives. The vagina slowly-releasing administration system has the following advantages: (1) the medicament can be controlled for continuous releasing administration for 2-7 days; (2) the biological adhesiveness is good, and no leakage occurs; and (3) the administration frequency is reduced so as to facilitate the administration of patients.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a sustained-release drug delivery system that can be used for vaginal delivery. technical background [0002] Scholars at home and abroad have done a lot of research on vaginal drug administration, which are mainly divided into two situations, one is that the drug exerts its effect locally, and the other is that the drug exerts its effect after being absorbed through the vaginal mucosa. Vaginal topical administration can be effectively used in the treatment of infection, endometriosis, uterine fibroids, contraception, and labor induction. Since the vagina is rich in capillaries and lymphatic capillaries, has a large mucosal surface area, and has good permeability to many drugs, it is also an effective way for systemic drug delivery, especially suitable for systemic drug delivery of protein and polypeptide drugs. Because vaginal administration is safe, effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K47/36A61K47/32A61K47/34A61P15/02A61P15/00A61K47/10
Inventor 巩洪刚常建晖邓树海
Owner 济南宏瑞创博医药科技开发有限公司
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